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PIN1 Products

(Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].

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Featured PIN1 Categories

PIN1 Antibodies

High quality antibodies with extensive validation data.

PIN1 ELISA Kits

Reliable ELISA kits for a wide range of species.

PIN1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PIN1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, FACS, IHC (p)
Validations
  • (5)
Cat. No. ABIN652906
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF, FACS
Validations
  • (9)
Cat. No. ABIN3028920
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (4)
Cat. No. ABIN3022930
Quantity 100 μL
Datasheet Datasheet

Recommended PIN1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6974378
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969199
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958454
Quantity 96 tests
Datasheet Datasheet

Recommended PIN1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124343
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN666676
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315108
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our PIN1 products

Zhao, Zhang, Ding, Cao, Qi, Wang: "Pin1 and secondary hyperparathyroidism of chronic kidney disease: gene polymorphisms and protein levels." in: Renal failure, Vol. 39, Issue 1, pp. 159-165, (2017) (PubMed).

Islam, Bae, Yoon, Woo, Baek, Kim, Uchida, Ryoo: "Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP." in: Journal of cellular physiology, Vol. 229, Issue 12, pp. 2166-74, (2014) (PubMed).

Yoon, Islam, Cho, Ryu, Shin, Woo, Baek, Ryoo: "Pin1 plays a critical role as a molecular switch in canonical BMP signaling." in: Journal of cellular physiology, Vol. 230, Issue 3, pp. 640-7, (2014) (PubMed).

Zhang, Zhang, Gao, Wang, Liu: "Regulation of the microRNA 200b (miRNA-200b) by transcriptional regulators PEA3 and ELK-1 protein affects expression of Pin1 protein to control anoikis." in: The Journal of biological chemistry, Vol. 288, Issue 45, pp. 32742-52, (2013) (PubMed).

Lucchetti, Caligiuri, Toffoli, Giordano, Rizzolio: "The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer." in: PLoS ONE, Vol. 8, Issue 2, pp. e55355, (2013) (PubMed).

La Montagna, Caligiuri, Maranta, Lucchetti, Esposito, Paggi, Toffoli, Rizzolio, Giordano: "Androgen receptor serine 81 mediates Pin1 interaction and activity." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 18, pp. 3415-20, (2013) (PubMed).

Rizzolio, Lucchetti, Caligiuri, Marchesi, Caputo, Klein-Szanto, Bagella, Castronovo, Giordano: "Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1." in: Cell death and differentiation, Vol. 19, Issue 7, pp. 1152-61, (2012) (PubMed).

Pani, Menigatti, Schubert, Hess, Gerrits, Klempnauer, Ferrari: "Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity." in: Biochimica et biophysica acta, Vol. 1783, Issue 6, pp. 1121-8, (2008) (PubMed).

Barone, Desouza, Freeman: "Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity." in: Journal of neurochemistry, Vol. 106, Issue 2, pp. 734-45, (2008) (PubMed).

Lim, Balastik, Lee, Nakamura, Liou, Sun, Finn, Pastorino, Lee, Lu: "Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy." in: The Journal of clinical investigation, Vol. 118, Issue 5, pp. 1877-89, (2008) (PubMed).

Synonyms and alternative names related to PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1), peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (Pin1), peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1), peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog (pin1.S), protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Pin1), peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog (pin1.L), peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (ppiD), peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PITG_11123), peptidyl-prolyl cis-trans isomerase Pin1 (pin1), peptidyl-prolyl cis-trans isomerase Pin1 (LOC103419188), 0610025L01Rik, D9Bwg1161e, DOD, dod, MdPin1, pin1, Pin1, pin1a, pin1b, PPIase pin1, UBL5, ubl5, zgc:73206

Protein level used designations for PIN1

  • PPIase Pin1
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
  • rotamase Pin1
  • protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1
  • prolyl isomerase Pin1
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 a
  • peptidyl-prolyl cis-trans isomerase Pin1
  • prolyl isomerase Pin1 b
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 b
  • Pin1-type peptidyl-prolyl cis/trans isomerase
  • Rotamase Pin1
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