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PIK3C2B Products

(Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 beta (PIK3C2B))

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The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008].

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Featured PIK3C2B Categories

PIK3C2B Antibodies

High quality antibodies with extensive validation data.

PIK3C2B Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PIK3C2B Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (8)
Cat. No. ABIN1500199
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (4)
Cat. No. ABIN518887
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p), IF
Validations
  • (4)
Cat. No. ABIN1500198
Quantity 100 μL
Datasheet Datasheet

Recommended PIK3C2B Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315065
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7405546
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2728944
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our PIK3C2B products

Kolic, Manning Fox, Chepurny, Spigelman, Ferdaoussi, Schwede, Holz, MacDonald: "PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets." in: Molecular metabolism, Vol. 5, Issue 7, pp. 459-71, (2016) (PubMed).

Norris, Pombo, Shirley, Blevins, Tablin: "Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia." in: Journal of veterinary internal medicine, Vol. 29, Issue 5, pp. 1387-94, (2016) (PubMed).

Arcaro, Volinia, Zvelebil, Stein, Watton, Layton, Gout, Ahmadi, Downward, Waterfield: "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity." in: The Journal of biological chemistry, Vol. 273, Issue 49, pp. 33082-90, (1999) (PubMed).

Synonyms and alternative names related to PIK3C2B

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (Pik3c2b), phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (PIK3C2B), C2-PI3K

Protein level used designations for PIK3C2B

  • nuclear cap binding protein subunit 2
  • phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta
  • phosphoinositide-3-kinase, class 2, beta polypeptide
  • PI3K-C2-beta
  • PI3K-C2beta
  • PTDINS-3-kinase C2 beta
  • phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide
  • phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
  • phosphoinositide 3-kinase-C2-beta
  • ptdIns-3-kinase C2 subunit beta
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