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PIAS4 Products

(Protein Inhibitor of Activated STAT, 4 (PIAS4))

Categories

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

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Featured PIAS4 Categories

PIAS4 Antibodies

High quality antibodies with extensive validation data.

PIAS4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PIAS4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6264199
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
  • (2)
Cat. No. ABIN388061
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN388062
Quantity 400 μL
Datasheet Datasheet

Recommended PIAS4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381423
Quantity 96 tests
Datasheet Datasheet

Recommended PIAS4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124650
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314996
Quantity 25 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424143
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PIAS4 products

Alshareeda, Negm, Green, Nolan, Tighe, Albarakati, Sultana, Madhusudan, Ellis, Rakha: "SUMOylation proteins in breast cancer." in: Breast cancer research and treatment, Vol. 144, Issue 3, pp. 519-30, (2014) (PubMed).

Shima, Suzuki, Sun, Kono, Shi, Kinomura, Horikoshi, Ikura, Ikura, Kanaar, Igarashi, Saitoh, Kurumizaka, Tashiro: "Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage." in: Journal of cell science, Vol. 126, Issue Pt 22, pp. 5284-92, (2013) (PubMed).

Fuhs, Insel: "Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization." in: The Journal of biological chemistry, Vol. 286, Issue 17, pp. 14830-41, (2011) (PubMed).

Tong, Shen, Wang, Kan, Wang, Li, Wang, Yang, Guo: "DNA ploidy cytometry testing for cervical cancer screening in China (DNACIC Trial): a prospective randomized, controlled trial." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 20, pp. 6438-45, (2009) (PubMed).

La Salle, Sun, Zhang, Matunis, Handel: "Developmental control of sumoylation pathway proteins in mouse male germ cells." in: Developmental biology, Vol. 321, Issue 1, pp. 227-37, (2008) (PubMed).

Brayman, Dharmaraj, Lagow, Carson: "MUC1 expression is repressed by protein inhibitor of activated signal transducer and activator of transcription-y." in: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 11, pp. 2725-37, (2007) (PubMed).

Albor, El-Hizawi, Horn, Laederich, Frosk, Wrogemann, Kulesz-Martin et al.: "The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through ..." in: The Journal of biological chemistry, Vol. 281, Issue 35, pp. 25850-66, (2006) (PubMed).

Bischof, Schwamborn, Martin, Werner, Sustmann, Grosschedl, Dejean: "The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis." in: Molecular cell, Vol. 22, Issue 6, pp. 783-94, (2006) (PubMed).

Ihara, Yamamoto, Kikuchi: "SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4." in: Molecular and cellular biology, Vol. 25, Issue 9, pp. 3506-18, (2005) (PubMed).

Zhang, Xu, Han, Wei, Shu: "PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis." in: FEBS letters, Vol. 570, Issue 1-3, pp. 97-101, (2004) (PubMed).

Synonyms and alternative names related to PIAS4

protein inhibitor of activated STAT 4 (PIAS4), protein inhibitor of activated STAT, 4 (Pias4), protein inhibitor of activated STAT, 4a (pias4a), protein inhibitor of activated STAT 4 L homeolog (pias4.L), protein inhibitor of activated STAT 4 (pias4), protein inhibitor of activated STAT 4 (Pias4), protein inhibitor of activated STAT, 4b (pias4b), LOC100219439, Pias-gamma, pias4, pias4l, Piasg, piasg, PIASY, piasy, wu:fc54c11, wu:fi18c10, wu:fi20e09, wu:fi26h11, wu:fk93f11, zgc:63923, zgc:66410, ZMIZ6, zmiz6

Protein level used designations for PIAS4

  • E3 SUMO-protein ligase PIAS4
  • PIAS-gamma
  • protein inhibitor of activated STAT protein 4
  • protein inhibitor of activated STAT protein PIASy
  • protein inhibitor of activated STAT protein gamma
  • zinc finger, MIZ-type containing 6
  • protein inhibitor of activated STAT 4
  • protein inhibitor of activated STAT, 4
  • E3 SUMO-protein ligase PIAS4-like
  • e3 SUMO-protein ligase PIAS4-like
  • protein inhibitor of activated STAT PIASy
  • protein inhibitor of activated STAT, 4b
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