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Phospholipase C gamma 2 Products

(Phospholipase C gamma 2 (PLCG2))

Categories

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. [provided by RefSeq, Sep 2011].

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Featured Phospholipase C gamma 2 Categories

Phospholipase C gamma 2 Antibodies

High quality antibodies with extensive validation data.

Phospholipase C gamma 2 ELISA Kits

Reliable ELISA kits for a wide range of species.

Phospholipase C gamma 2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Phospholipase C gamma 2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (5)
Cat. No. ABIN3023145
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (4)
Cat. No. ABIN6256017
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA
Validations
  • (4)
Cat. No. ABIN5542311
Quantity 100 μL
Datasheet Datasheet

Recommended Phospholipase C gamma 2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969306
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958573
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380130
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended Phospholipase C gamma 2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7397702
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094665
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136487
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our Phospholipase C gamma 2 products

Diaz-Flores, Goldschmidt, Depeille, Ng, Akutagawa, Krisman, Crone, Burgess, Williams, Houseman, Shokat, Sampath, Bollag, Roose, Braun, Shannon: "PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras." in: Science signaling, Vol. 6, Issue 304, pp. ra105, (2013) (PubMed).

Holodick, Tumang, Rothstein: "Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells." in: Molecular immunology, Vol. 46, Issue 15, pp. 3029-36, (2009) (PubMed).

Kim, Sekiya, Poulin, Bae, Rhee: "Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 9986-99, (2004) (PubMed).

Suzuki-Inoue, Wilde, Andrews, Auger, Siraganian, Sekiya, Rhee, Watson: "Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 1023-9, (2004) (PubMed).

Humphries, Dangelmaier, Sommer, Kipp, Kato, Griffith, Bakman, Turk, Daniel, Rawlings: "Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker." in: The Journal of biological chemistry, Vol. 279, Issue 36, pp. 37651-61, (2004) (PubMed).

Watanabe, Hashimoto, Ishiai, Matsushita, Baba, Kishimoto, Kurosaki, Tsukada: "Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling." in: The Journal of biological chemistry, Vol. 276, Issue 42, pp. 38595-601, (2001) (PubMed).

Yue, Ku, Liu, Simon, Sanborn: "Molecular mechanism of the inhibition of phospholipase C beta 3 by protein kinase C." in: The Journal of biological chemistry, Vol. 275, Issue 39, pp. 30220-5, (2000) (PubMed).

Ohta, Matsui, Nazawa, Kagawa: "Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes." in: FEBS letters, Vol. 242, Issue 1, pp. 31-5, (1989) (PubMed).

Synonyms and alternative names related to Phospholipase C gamma 2

phospholipase C, gamma 2 (Plcg2), phospholipase C gamma 2 (PLCG2), phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2), phospholipase C gamma 2 (Plcg2), APLAID, FCAS3, Plcg-2, PLCgamma2

Protein level used designations for Phospholipase C gamma 2

  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
  • PLC-gamma-2
  • phosphoinositide phospholipase C-gamma-2
  • phospholipase C-gamma-2
  • PLC-IV
  • phosphoinositide phospholipase C
  • phospholipase C-IV
  • phosphatidylinositol-specific phospholipase C
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