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PHLPP2 Products

(PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Categories

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.

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Featured PHLPP2 Categories

PHLPP2 Antibodies

High quality antibodies with extensive validation data.

PHLPP2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PHLPP2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC (p), FACS
Validations
  • (3)
Cat. No. ABIN652395
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IHC (p), IP
Validations
  • (2)
Cat. No. ABIN962593
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN392229
Quantity 400 μL
Datasheet Datasheet

Recommended PHLPP2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6212123
Quantity 96 tests
Datasheet Datasheet

Recommended PHLPP2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124383
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094545
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136302
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PHLPP2 products

Rajala, Gupta, Anderson, Rajala: "Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection." in: Mitochondrion, Vol. 13, Issue 6, pp. 566-76, (2013) (PubMed).

Sangai, Akcakanat, Chen, Tarco, Wu, Do, Miller, Arteaga, Mills, Gonzalez-Angulo, Meric-Bernstam: "Biomarkers of response to Akt inhibitor MK-2206 in breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 20, pp. 5816-28, (2012) (PubMed).

Gao, Furnari, Newton: "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." in: Molecular cell, Vol. 18, Issue 1, pp. 13-24, (2005) (PubMed).

Synonyms and alternative names related to PHLPP2

PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2), PH domain and leucine rich repeat protein phosphatase 2 S homeolog (phlpp2.S), PH domain and leucine rich repeat protein phosphatase 2 (phlpp2), PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), AI481772, C130044A18Rik, PHLPPL, phlppl, Phlppl, RGD1562857

Protein level used designations for PHLPP2

  • PH domain leucine-rich repeat-containing protein phosphatase 2
  • PH domain and leucine rich repeat protein phosphatase 2
  • PH domain leucine-rich repeat-containing protein phosphatase 2-like
  • GTPase activating protein and VPS9 domains 1
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