PHLPP1 Products
(PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
Categories
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].
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Featured PHLPP1 Categories
PHLPP1 Antibodies
High quality antibodies with extensive validation data.
Recommended PHLPP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN6145573
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7130610
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6264947
Quantity
100 μL
Datasheet
Datasheet
Recommended PHLPP1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6206653
Quantity
96 tests
Datasheet
Datasheet
Recommended PHLPP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
- (1)
Cat. No.
ABIN2728848
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our PHLPP1 products
: "RNA-binding Protein Trinucleotide repeat-containing 6A Regulates the Formation of Circular RNA 0006916, with Important Functions in Lung Cancer Cells." in: Carcinogenesis, (2018) (PubMed).: "Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." in: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).
: "Interactome of the negative regulator of nuclear import BRCA1-binding protein 2." in: Scientific reports, Vol. 5, pp. 9459, (2015) (PubMed).
: "Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1." in: Science signaling, Vol. 6, Issue 267, pp. ra19, (2013) (PubMed).
: "An ATP-site on-off switch that restricts phosphatase accessibility of Akt." in: Science signaling, Vol. 5, Issue 223, pp. ra37, (2012) (PubMed).
: "mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6510-20, (2011) (PubMed).
: "Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein ..." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19777-88, (2011) (PubMed).
: "Cell-type-specific regulation of raft-associated Akt signaling." in: Cell death & disease, Vol. 2, pp. e145, (2011) (PubMed).
: "IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects." in: Endocrinology, Vol. 151, Issue 8, pp. 3752-63, (2010) (PubMed).
: "Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN ..." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27900-10, (2010) (PubMed).
Synonyms and alternative names related to PHLPP1
PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), PH domain and leucine rich repeat protein phosphatase 1 (phlpp1), PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1), AI836256, mKIAA0606, PHLPP, Phlpp, PLEKHE1, Plekhe1, SCOP, ScopProtein level used designations for PHLPP1
- PH domain and leucine rich repeat protein phosphatase 1
- PH domain leucine-rich repeat-containing protein phosphatase 1-like
- PH domain leucine-rich repeat-containing protein phosphatase 1
- PH domain-containing family E member 1
- SCN circadian oscillatory protein
- pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
- suprachiasmatic nucleus circadian oscillatory protein
- pleckstrin homology domain-containing family E member 1
- Circadian Oscillatory Protein (SCOP)
- PH domain leucine-rich repeat protein phosphatase 1
- pleckstrin homology domain-containing family E protein 1
Did you look for something else?
- PHLDB3
- PHLDB2
- PHLDB1
- PHLDA3
- PHLDA2
- PHLDA1
- PHKG2
- PHKG1
- PHKB
- PHKA2
- PHKA1
- PHIP
- PHGDH
- PHF8
- PHF7
- PHF6
- PHF5A
- PHF3
- PHF23
- PHF21B
- PHLPP2
- PHNC2
- PHO85
- Phosducin
- Phosducin-Like
- Phosphatase and Actin Regulator 3
- Phosphatase and Actin Regulator 4
- Phosphatase and Tensin Homolog
- Phosphate Cytidylyltransferase 1, Choline, alpha
- Phosphate Cytidylyltransferase 1, Choline, beta
- Phosphate-Binding Protein PstS 1
- Phosphatidylinositol Antibody IgG/IgM
- Phosphatidylinositol Binding clathrin Assembly Protein
- Phosphatidylinositol Phosphate
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, beta
- Phospho Protein Kinase C
- Phospho-Extracellular Signal-Regulated Kinase
- PHOSPHO1
- PHOSPHO2
- Phosphodiesterase
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