PHGDH Products
(phosphoglycerate Dehydrogenase (PHGDH))
Categories
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011].
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Featured PHGDH Categories
PHGDH Antibodies
High quality antibodies with extensive validation data.
PHGDH ELISA Kits
Reliable ELISA kits for a wide range of species.
PHGDH Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PHGDH Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF, IP
Validations
- (1)
- (10)
Cat. No.
ABIN565240
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF, IP, IHC (fro), ICC
Validations
- (6)
Cat. No.
ABIN2855237
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (5)
Cat. No.
ABIN6145554
Quantity
100 μL
Datasheet
Datasheet
Recommended PHGDH ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
Cat. No.
ABIN6969482
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Various Species
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN2815100
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951683
Quantity
96 tests
Datasheet
Datasheet
Recommended PHGDH Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314910
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124414
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7479282
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PHGDH products
: "Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 21, pp. 5392-5406, (2018) (PubMed).: "Systematic analysis of mRNA expression profiles in NSCLC cell lines to screen metastasis-related genes." in: Molecular medicine reports, Vol. 14, Issue 6, pp. 5093-5103, (2017) (PubMed).
: "PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis." in: Cancer research, Vol. 76, Issue 15, pp. 4430-42, (2016) (PubMed).
: "An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation." in: Cancer & metabolism, Vol. 3, pp. 5, (2015) (PubMed).
: "Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability." in: Nucleic acids research, Vol. 43, Issue 7, pp. 3667-79, (2015) (PubMed).
: "NRF2 regulates serine biosynthesis in non-small cell lung cancer." in: Nature genetics, Vol. 47, Issue 12, pp. 1475-81, (2015) (PubMed).
: "Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells." in: Nature, Vol. 493, Issue 7433, pp. 542-6, (2013) (PubMed).
: "Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis." in: PLoS genetics, Vol. 8, Issue 3, pp. e1002573, (2012) (PubMed).
: "Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. ..." in: Nature, Vol. 476, Issue 7360, pp. 346-50, (2011) (PubMed).
: "Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis." in: Breast cancer research and treatment, Vol. 125, Issue 2, pp. 421-30, (2010) (PubMed).
Synonyms and alternative names related to PHGDH
phosphoglycerate dehydrogenase (phgdh), D-3-phosphoglycerate dehydrogenase (EDA9), D-3-phosphoglycerate dehydrogenase (serA), D-3-phosphoglycerate dehydrogenase (Sthe_2284), D-3-phosphoglycerate dehydrogenase (Dacet_1260), D-3-phosphoglycerate dehydrogenase (Mrub_0173), phosphoglycerate dehydrogenase (MMAH_RS07650), D-3-phosphoglycerate dehydrogenase (Arnit_0487), D-3-phosphoglycerate dehydrogenase (Ndas_0174), D-3-phosphoglycerate dehydrogenase (Mesil_2386), D-3-phosphoglycerate dehydrogenase (Slip_0010), D-3-phosphoglycerate dehydrogenase (Trad_0302), D-3-phosphoglycerate dehydrogenase (Acear_0027), D-3-phosphoglycerate dehydrogenase (Mahau_0665), phosphoglycerate dehydrogenase (MZHIL_RS05165), D-3-phosphoglycerate dehydrogenase (Mesop_1331), D-3-phosphoglycerate dehydrogenase (Thein_0855), 3-phosphoglycerate dehydrogenase (Phgdh), phosphoglycerate dehydrogenase (PHGDH), phosphoglycerate dehydrogenase (Phgdh), 3-PGDH, 3PGDH, 4930479N23, A10, ECK2909, embryo sac development arrest 9, F10M10.7, fb38f06, JW2880, PDG, PGAD, PGD, PGDH, SERA, wu:fb38f06, zgc:65956Protein level used designations for PHGDH
- D-3-phosphoglycerate dehydrogenase
- 3-phosphoglycerate dehyrogenase
- 3-phosphoglycerate dehydrogenase
- 3-PGDH
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