PHD1 Products
(Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))
Categories
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011].
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Featured PHD1 Categories
PHD1 Antibodies
High quality antibodies with extensive validation data.
PHD1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PHD1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7151444
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN652648
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Cow, Guinea Pig, Human
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN6736715
Quantity
100 μL
Datasheet
Datasheet
Recommended PHD1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6216907
Quantity
96 tests
Datasheet
Datasheet
Recommended PHD1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352447
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2720027
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3092321
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PHD1 products
: "Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells." in: Cancer letters, Vol. 390, pp. 11-20, (2017) (PubMed).: "Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic-Ischemic Injury in the Neonatal Rat." in: Neurochemical research, Vol. 41, Issue 3, pp. 515-22, (2016) (PubMed).
: "The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer." in: Nature cell biology, Vol. 18, Issue 2, pp. 213-24, (2016) (PubMed).
: "EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor." in: Oncotarget, Vol. 8, Issue 4, pp. 6787-6795, (2016) (PubMed).
: "PHD1 regulates p53-mediated colorectal cancer chemoresistance." in: EMBO molecular medicine, Vol. 7, Issue 10, pp. 1350-65, (2015) (PubMed).
: "Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27." in: Molecular cancer, Vol. 14, pp. 143, (2015) (PubMed).
: "EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer." in: The EMBO journal, Vol. 34, Issue 23, pp. 2953-70, (2015) (PubMed).
: "Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase." in: Genes & development, Vol. 28, Issue 13, pp. 1429-44, (2014) (PubMed).
: "Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells." in: PLoS pathogens, Vol. 10, Issue 9, pp. e1004400, (2014) (PubMed).
: "High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 1, pp. 206-17, (2014) (PubMed).
Synonyms and alternative names related to PHD1
egl-9 family hypoxia-inducible factor 1 (egln1), egl-9 family hypoxia inducible factor 2 (EGLN2), Egl nine homolog 2 (egln2), egl-9 family hypoxia-inducible factor 2 L homeolog (egln2.L), egl-9 family hypoxia-inducible factor 2 (Egln2), 0610011A13Rik, C85656, egln2, EIT6, Hif-p4h-1, HIF-PH1, HIFPH1, HPH-1, HPH-3, Ier4, PHD-1, PHD1, Phd1, phd2, SM-20Protein level used designations for PHD1
- EGL nine homolog 2
- egl nine homolog 2
- Egl nine homolog 2
- EGL nine (C.elegans) homolog 2
- egl nine homolog 2 (C. elegans)
- egl nine homolog 2-like
- HIF-PH1
- HIF-prolyl hydroxylase 1
- HPH-1
- falkor
- hypoxia-inducible factor prolyl hydroxylase 1
- immediate early response 4
- prolyl hydroxylase domain-containing protein 1
- HIF-1alpha prolyl-4-hydroxylase-1
- estrogen-induced tag 6
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