PGC Products
(Pepsinogen C (PGC))
Categories
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009].
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Featured PGC Categories
PGC Antibodies
High quality antibodies with extensive validation data.
PGC ELISA Kits
Reliable ELISA kits for a wide range of species.
PGC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PGC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN3016695
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7431245
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN6266376
Quantity
100 μL
Datasheet
Datasheet
Recommended PGC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
Cat. No.
ABIN6730888
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
Cat. No.
ABIN6574145
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958438
Quantity
96 tests
Datasheet
Datasheet
Recommended PGC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314794
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7321216
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7389107
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PGC products
: "Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity." in: Nature communications, Vol. 9, Issue 1, pp. 2419, (2019) (PubMed).: "Troy is expressed in human stomach mucosa and a novel putative prognostic marker of intestinal type gastric cancer." in: Oncotarget, Vol. 8, Issue 31, pp. 50557-50569, (2017) (PubMed).
: "Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis." in: Cancer research, Vol. 65, Issue 14, pp. 6220-7, (2005) (PubMed).
Synonyms and alternative names related to PGC
progastricsin (pepsinogen C) (PGC), progastricsin (PGC), progastricsin (pepsinogen C) (Pgc), progastricsin (Pgc), 2210410L06Rik, CPGC, gastricsin, Gastricsin, PEPC, Pg-1, PG1, PGC, PGII, PGNC, Upg-1, Upg1Protein level used designations for PGC
- gastricsin
- pepsinogen C
- pepsin C
- pepsinogen group II
- preprogastricsin
- urinary pepsinogen 1
- Urinary pepsinogen 1
- gastricsin-like
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