PFKFB2 Products
(6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 2 (PFKFB2))
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The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured PFKFB2 Categories
PFKFB2 Antibodies
High quality antibodies with extensive validation data.
PFKFB2 ELISA Kits
Reliable ELISA kits for a wide range of species.
PFKFB2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PFKFB2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7142693
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
- (2)
Cat. No.
ABIN392769
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN6145483
Quantity
100 μL
Datasheet
Datasheet
Recommended PFKFB2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380333
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended PFKFB2 Proteins
Latest Publications for our PFKFB2 products
: "Label-free quantitative proteomic analysis of right ventricular remodeling in infant Tetralogy of Fallot patients." in: Journal of proteomics, Vol. 84, pp. 78-91, (2013) (PubMed).: "Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids." in: The Journal of biological chemistry, Vol. 288, Issue 15, pp. 10640-51, (2013) (PubMed).
: "Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells." in: BMC cancer, Vol. 10, pp. 638, (2010) (PubMed).
: "Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases." in: The Journal of biological chemistry, Vol. 284, Issue 36, pp. 24223-32, (2009) (PubMed).
: "A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells." in: The Biochemical journal, Vol. 411, Issue 1, pp. 41-51, (2008) (PubMed).
: "Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells." in: Oncogene, Vol. 21, Issue 55, pp. 8414-27, (2002) (PubMed).
: "Isolation of novel heart-specific genes using the BodyMap database." in: Genomics, Vol. 74, Issue 1, pp. 115-20, (2001) (PubMed).
Synonyms and alternative names related to PFKFB2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a (pfkfb2a), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (pfkfb2), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (Pfkfb2), 4930568D07Rik, PFK-2/FBPase-2, pfkfb2, RH2K, zgc:56282Protein level used designations for PFKFB2
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
- pfk-2/fbpase-2
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2-like
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
- 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme
- 6PF-2-K/Fru-2,6-P2ase 2
- PFK/FBPase 2
- PFKFB, cardiac
- fructose-2,6-bisphosphatase, cardiac isozyme
- 6PF-2-K/Fru-2,6-P2ase heart-type isozyme
- PFK-2/FBPase-2 gene B
- 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (heart)
- PFK-2/FBPase-2
- fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase
- 6-phosphofructo-2-kinase /fructose-2,6-bisphosphatase
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