Lysine (K)-Specific Demethylase 6A (KDM6A) (Middle Region) Peptide
KDM6A
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all KDM6A products
- KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-UTX antibody (Catalog #: ARP39483_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))
- Synonyms
- KABUK2 Peptide, UTX Peptide, bA386N14.2 Peptide, Utx Peptide, si:ch211-222m21.1 Peptide, utx Peptide, kdm6a Peptide, tutx Peptide, uty Peptide, xtutx Peptide, lysine demethylase 6A Peptide, lysine-specific demethylase 6A Peptide, lysine (K)-specific demethylase 6A Peptide, lysine demethylase 6A S homeolog Peptide, KDM6A Peptide, LOC100539898 Peptide, Kdm6a Peptide, kdm6a Peptide, kdm6a.S Peptide
- Background
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UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
Alias Symbols: DKFZp686A03225, MGC141941, bA386N14.2, UTX, KABUK2
Protein Interaction Partner: SMAD9,TLE1,ASH2L,C13orf23,HIST3H3,MLL2,MLL3,N4BP2,NCOA6,PAXIP1,PPP6R3,RBBP5,TLE1,WDR5,ZNF281
Protein Size: 1401 - Molecular Weight
- 154 kDa
- Gene ID
- 7403
- NCBI Accession
- NM_021140, NP_066963
- UniProt
- O15550
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