serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (Middle Region) Peptide
SPTLC1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SPTLC1 products
- SPTLC1 (serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SPTLC1 antibody (Catalog #: ARP46722_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SPTLC1 (serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1))
- Synonyms
- ATSPT1 Peptide, SERINE PALMITOYLTRANSFERASE 1 Peptide, serine palmitoyltransferase 1 Peptide, Afu6g00300 Peptide, HSAN1 Peptide, HSN1 Peptide, LBC1 Peptide, LCB1 Peptide, SPT1 Peptide, SPTI Peptide, wu:fc75h04 Peptide, wu:fp41c08 Peptide, zgc:112247 Peptide, AW552086 Peptide, C77762 Peptide, E030036H05 Peptide, Lcb1 Peptide, RGD1306617 Peptide, Spt1 Peptide, serine palmitoyltransferase 1 Peptide, Serine palmitoyltransferase 1 Peptide, serine palmitoyltransferase long chain base subunit 1 Peptide, serine palmitoyltransferase, long chain base subunit 1 Peptide, serine palmitoyltransferase, long chain base subunit 1 L homeolog Peptide, SPT1 Peptide, AFUA_6G00300 Peptide, PAS_FragB_0040 Peptide, SPTLC1 Peptide, sptlc1 Peptide, sptlc1.L Peptide, Sptlc1 Peptide
- Background
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Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPTLC1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 gene were identified in patients with hereditary sensory neuropathy type 1. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
Alias Symbols: HSAN, HSAN1, HSN1, LBC1, LCB1, MGC14645, SPT1, SPTI, hLCB1
Protein Interaction Partner: ABCA1,SPTLC2,C20orf24,MAGED1,ORMDL3,RGS20
Protein Size: 473 - Molecular Weight
- 53 kDa
- Gene ID
- 10558
- NCBI Accession
- NM_006415, NP_006406
- UniProt
- O15269
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