SH2 Domain Containing 1A (SH2D1A) (C-Term) Peptide
SH2D1A
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SH2D1A products
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SH2D1A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Synonyms
- DSHP Peptide, EBVS Peptide, IMD5 Peptide, LYP Peptide, MTCP1 Peptide, SAP Peptide, SAP/SH2D1A Peptide, XLP Peptide, XLPD Peptide, RGD1562408 Peptide, Gm686 Peptide, SH2D1A Peptide, SH2 domain containing 1A Peptide, SH2D1A Peptide, Sh2d1a Peptide
- Background
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SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Alias Symbols: DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD, SAP/SH2D1A
Protein Interaction Partner: CD244,CD84,LY9,SLAMF1,SLAMF1,ARHGEF6,ARHGEF7,CD84,DOK1,FYB,FYN,GRB2,LCK,LY9,SLAMF1,SLAMF6,SLAMF7,CD244,CD84,DOK1,FYN,LY9,SLAMF1,SLAMF6
Protein Size: 128 - Molecular Weight
- 14 kDa
- Gene ID
- 4068
- NCBI Accession
- NM_002351, NP_002342
- UniProt
- O60880
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