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Ring Finger Protein 11-Like (RNF11L) (C-Term) Peptide

RNF11L Reactivity: Human, Rat Host: Synthetic BP, WB
Catalog No. ABIN983037
  • Target
    RNF11L (Ring Finger Protein 11-Like (RNF11L))
    Protein Region
    C-Term
    Origin
    Human, Rat
    Source
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    GLIQHLPKGG YDPGRDGSEK KIRECVICMM DFVYGDPIRF LPCMHIYHLD
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-Rnf11l Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    RNF11L (Ring Finger Protein 11-Like (RNF11L))
    Synonyms
    Rnf11 Peptide, ring finger protein 11-like 2 Peptide, Rnf11l2 Peptide
    Background
    Rnf11l is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Rnf11l promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Rnf11l recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

    Alias Symbols: Rnf11

    Protein Size: 280
    Molecular Weight
    30 kDa
    Gene ID
    316552
    NCBI Accession
    XM_237327, XP_237327
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