Presenilin Enhancer 2 Homolog (PSENEN) (C-Term) Peptide
PSENEN
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PEN2 (PSENEN) products
- PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PSENEN Antibody(ARP59439_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))
- Background
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Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Alias Symbols: MDS033, MSTP064, PEN-2, PEN2
Protein Interaction Partner: APH1A,NCSTN,PSEN1,APH1A,NCSTN,PSEN1,PSEN2,TMED10,APH1A,NCSTN,PSEN1,PSEN2
Protein Size: 101 - Molecular Weight
- 12 kDa
- Gene ID
- 55851
- NCBI Accession
- NM_172341, NP_758844
- UniProt
- Q9NZ42
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