Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1) Peptide
NR2C1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all NR2C1 products
- NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NR2C1 antibody (Catalog #: ARP38287_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NR2C1 (Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))
- Synonyms
- TR2 Peptide, NR2C1 Peptide, dor2 Peptide, tr2-11 Peptide, xDOR2 Peptide, DKFZp468M0512 Peptide, si:dkey-183c16.2 Peptide, zgc:110672 Peptide, 4831444H07Rik Peptide, 80.3 Peptide, Eenr Peptide, Tr2-11 Peptide, Tr2 Peptide, Psg4 Peptide, TR2-11 Peptide, PSG9 Peptide, nr2c1 Peptide, nuclear receptor subfamily 2 group C member 1 Peptide, nuclear receptor subfamily 2 group C member 1 S homeolog Peptide, nuclear receptor subfamily 2, group C, member 1 Peptide, pregnancy specific beta-1-glycoprotein 4 Peptide, nuclear receptor subfamily 2 group C member 1 L homeolog Peptide, NR2C1 Peptide, nr2c1.S Peptide, nr2c1 Peptide, Nr2c1 Peptide, PSG4 Peptide, nr2c1.L Peptide
- Background
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The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites
Alias Symbols: TR2, TR2-11
Protein Interaction Partner: AR,ESR1,HDAC3,HDAC4,NR2C2,NRIP1,AR,ESR1,HDAC3,HDAC4
Protein Size: 603 - Molecular Weight
- 67 kDa
- Gene ID
- 7181
- NCBI Accession
- NM_003297, NP_003288
- UniProt
- Q15625
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