Non-POU Domain Containing, Octamer-Binding (NONO) Peptide
NONO
Reactivity: Human
Host: Synthetic
BP, WB, ICC
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- Target See all NONO products
- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunocytochemistry (ICC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NONO antibody (Catalog #: ARP40715_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
- Background
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NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
Alias Symbols: P54, NMT55, NRB54, P54NRB
Protein Interaction Partner: PCNA,SFPQ,AR,CA2,FXR2,MAD1L1,NONO,PIN1,PLEKHF2,POLR2A,PSPC1,SFPQ,SPI1,ZNRD1,AR,CA2,FXR2,MAD1L1,NONO,PIN1,PLEKHF2,PMS1,PSPC1,Polr2a,SFPQ,SOCS3,SPI1,ZNRD1
Protein Size: 471 - Molecular Weight
- 52 kDa
- Gene ID
- 4841
- NCBI Accession
- NM_007363, NP_031389
- UniProt
- Q15233
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