Neurofibromin 2 (NF2) (C-Term) Peptide
NF2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Merlin (NF2) products
- Merlin (NF2) (Neurofibromin 2 (NF2))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MAEESERRAK EADQLKQDLQ EAREAERRAK QKLLEIATKP TYPPMNPIPA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NF2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Merlin (NF2) (Neurofibromin 2 (NF2))
- Background
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This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
Alias Symbols: ACN, BANF, SCH
Protein Interaction Partner: EZR,HGS,NF2,PAK1,SDCBP,SLC9A3R1,TARBP2,TSC1,CD44,CTNNB1,ERBB2,EZR,HGS,ITGB1,NF2,PAK1,PXN,RALGDS,SCHIP1,SDCBP,SGSM3,SLC9A3R1,SPTBN1,TARBP2,TSC1,XPO1,AGAP2,AKT1,AMOT,ARHGAP32,CD44,CUL4A,DDB1,EZR,HGS,MED28,NF2,PXN,PYGO2,RIT1,SCHIP1,SDCBP,SGSM3,SLC9A3R1,SOS1,
Protein Size: 507 - Molecular Weight
- 56 kDa
- Gene ID
- 4771
- NCBI Accession
- NM_181830, NP_861968
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