Mediator of Cell Motility 1 (MEMO1) (Middle Region) Peptide
MEMO1
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all MEMO1 products
- MEMO1 (Mediator of Cell Motility 1 (MEMO1))
- Protein Region
- Middle Region
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Memo1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MEMO1 (Mediator of Cell Motility 1 (MEMO1))
- Synonyms
- MGC89105 Peptide, C2orf4 Peptide, MEMO Peptide, NS5ATP7 Peptide, 0610016J10Rik Peptide, D930048L02Rik Peptide, RGD1309929 Peptide, fi04d12 Peptide, wu:fi04d12 Peptide, zgc:55290 Peptide, mediator of cell motility 1 Peptide, mediator of cell motility 1 L homeolog Peptide, MEMO1 Peptide, memo1 Peptide, Memo1 Peptide, memo1.L Peptide
- Background
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Memo1 may control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. It is a mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Alias Symbols: 0610016J10Rik, D930048L02Rik
Protein Size: 297 - Molecular Weight
- 34 kDa
- Gene ID
- 76890
- NCBI Accession
- NM_133771, NP_598532
- UniProt
- Q91VH6
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