Minichromosome Maintenance Deficient 4 (MCM4) Peptide
MCM4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MCM4 products
- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MCM4 antibody (Catalog #: ARP36649_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
- Synonyms
- cdc21 Peptide, CDC21 Peptide, CDC54 Peptide, NKCD Peptide, NKGCD Peptide, P1-CDC21 Peptide, hCdc21 Peptide, 19G Peptide, AI325074 Peptide, AU045576 Peptide, Cdc21 Peptide, Mcmd4 Peptide, mKIAA4003 Peptide, mcdc21 Peptide, cb1025 Peptide, fc12c09 Peptide, fj85g09 Peptide, hm:zeh1616 Peptide, wu:fc12c09 Peptide, wu:fj85g09 Peptide, zeh1616 Peptide, minichromosome maintenance complex component 4 L homeolog Peptide, minichromosome maintenance complex component 4 S homeolog Peptide, minichromosome maintenance complex component 4 Peptide, mcm4.L Peptide, mcm4.S Peptide, MCM4 Peptide, mcm4 Peptide, Mcm4 Peptide
- Background
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The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. The MCM4 gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks.
Alias Symbols: CDC21, CDC54, hCdc21, P1-CDC21
Protein Interaction Partner: MCM6,MCM7,MCM4,MCM6,MCM7,CCNA1,CDC5L,CDC7,CDK1,CDK2,MCM10,MCM2,MCM3,MCM4,MCM6,MCM7,MCM8,ORC2L,ORC6L,SSRP1,SUPT16H,CDC7,CDK2,CDT1,DBF4,ING5,MCM2,MCM4,MCM5,MCM6,MCM7,MCM8,ORC1L,ORC2L,ORC3L,ORC4L,ORC5L,ORC6L,RPA1,RPA2,USP7
Protein Size: 863 - Molecular Weight
- 95 kDa
- Gene ID
- 4173
- NCBI Accession
- NM_005914, NP_005905
- UniProt
- P33991
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