F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) Peptide
FBXW7
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all FBXW7 products
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KTGEFIRNLV TLESGGSGGV VWRIRASNTK LVCAVGSRNG TEETKLLVLD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-FBXW7 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Background
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class, in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FBXW7,FBW7, FBX30, SEL10,
Protein Size: 707 - Molecular Weight
- 66 kDa
- Gene ID
- 55294
- NCBI Accession
- NP_361014
- UniProt
- Q969H0
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