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CDC45 Cell Division Cycle 45 (CDC45L) (C-Term) Peptide

CDC45L Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN974737
  • Target
    CDC45L (CDC45 Cell Division Cycle 45 (CDC45L))
    Protein Region
    C-Term
    Origin
    Human
    Source
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-CDC45L antibody (Catalog #: ARP51333_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    CDC45L (CDC45 Cell Division Cycle 45 (CDC45L))
    Synonyms
    CDC45L Peptide, CDC45L2 Peptide, PORC-PI-1 Peptide, Cdc45l Peptide, cell division cycle 45 Peptide, CDC45 Peptide, Cdc45 Peptide
    Background
    CDC45L was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

    Alias Symbols: CDC45, CDC45L2, PORC-PI-1, CDC45L

    Protein Interaction Partner: CDK4,CDKN1A,CDKN2A,MCM10,MCM3,MCM7,ORC2L,ORC3L,ORC5L,POLA1,MCM3,MCM6,MCM7,ORC1L,ORC2L,ORC6L,POLA1

    Protein Size: 566
    Molecular Weight
    65 kDa
    Gene ID
    8318
    NCBI Accession
    NM_003504, NP_003495
    UniProt
    O75419
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