Caspase 3 (CASP3) Peptide
CASP3
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all Caspase 3 (CASP3) products
- Caspase 3 (CASP3)
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CASP3 antibody (Catalog #: AVARP00021_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Caspase 3 (CASP3)
- Synonyms
- CPP32 Peptide, CPP32B Peptide, SCA-1 Peptide, A830040C14Rik Peptide, AC-3 Peptide, Apopain Peptide, CC3 Peptide, Caspase-3 Peptide, Lice Peptide, Yama Peptide, mldy Peptide, xcpp32 Peptide, casp3 Peptide, zgc:100890 Peptide, CASP-3 Peptide, caspase-3 Peptide, caspase 3 Peptide, caspase 3 S homeolog Peptide, caspase 3, apoptosis-related cysteine peptidase a Peptide, caspase 3, apoptosis-related cysteine peptidase Peptide, CASP3 Peptide, Casp3 Peptide, casp3.S Peptide, casp3a Peptide
- Background
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CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Alias Symbols: CPP32, SCA-1, CPP32B
Protein Interaction Partner: AR,ATN1,ATXN3,BIRC3,BIRC6,HTT,NDUFS1,NEO1,PARP1,PLEKHO1,XIAP,BIRC6,CFLAR,PSEN1,RB1,XIAP,ACIN1,ADD1,AIFM1,AKAP8,AKT1,APAF1,APP,AR,ARHGDIB,ATN1,BCAP31,BCAR1,BCL2,BID,BIRC2,BIRC3,BIRC5,BIRC6,BIRC7,BLM,BMX,BRCA1,CAD,CASP10,CASP3,CASP4,CASP6,CASP8,CASP9,CAST,CDC27,CDC42,CDH1,CDK11A,CDK11B,CDKN1A,CFLAR,CTNNB1,DCC,DCTN1,DEDD,DFFA,DSG3,EIF2AK2,EIF2S1,EIF3J,EIF4B,EIF4G2,FYN,GATA1,GOLGA3,GORASP1,GRIPAP1,GSN,GZMB,HCLS1,HIP1,HMGB1,HNRNPU,HSPD1,HSPE1,HTT,IL16,IL18,KCNIP3,KRT18,LMNB1,LYN,MAP4K1,MAPK8IP3,MAPT,MCL1,MDM2,MDM4,MEF2A,MET,MLH1,MYL3,NEDD4,NFE2L2,NMT2,PAK2,PARG,PDE10A,PDE5A,PICALM,PIP5K1A,PKN1,PKN2,PLA2G4A,PPP3CA,PRKCQ,PRKCZ,PRKDC,PSEN1,PSEN2,PSIP1,PSME3,PTBP1,PTMA,PXN,RABEP1,RAC1,RAD51,RASA1,RB1,RFC1,ROCK1,SARS2,SLK,SP1,SPTAN1,SREBF2,SRF,SRP72,STK24,STK3,STK4,TFAP2A,TGM2,TOP1,TRAF1,TRAF3,UBE4B,USO1,VAV1,VIM,WEE1,XIAP,YWHAE,BCL2,BID,BIRC2,BIRC3,BIRC5,BIRC7,BLM,BMX,CASP10,CASP2,CASP3,CASP6,CASP8,CFLAR,CFLAR,CTTN,DBNL,DCC,GORASP1,GRIPAP1,HCLS1,HSPD1,HSPE1,MAP3K14,MCL1,NDUFS1,PARG,SREBF2,SRP72,TNS4,TRAF3,USO1,XIAP
Protein Size: 277 - Molecular Weight
- 32 kDa
- Gene ID
- 836
- NCBI Accession
- NM_004346, NP_004337
- UniProt
- P42574
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