Alanyl (Membrane) Aminopeptidase (ANPEP) (N-Term) Peptide
ANPEP
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CD13 (ANPEP) products
- CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- VGGSQPPDID KTELVEPTEY LVVHLKGSLV KDSQYEMDSE FEGELADDLA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ANPEP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))
- Background
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Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.
Alias Symbols: APN, CD13, GP150, LAP1, P150, PEPN
Protein Interaction Partner: ANPEP,TM4SF1
Protein Size: 967 - Molecular Weight
- 106 kDa
- Gene ID
- 290
- NCBI Accession
- NM_001150, NP_001141
- UniProt
- P15144
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