GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) Peptide
GAPVD1
Reactivity: Mammalian
Host: Synthetic
BP, IHC, WB
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- Target See all GAPVD1 products
- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Sequence
- FKLFSEGLFS AKLFLTATLH EPIMQLLVED EDHLETDPNK LIERFSPSQQ
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of GAPVD1 antibody,
Alternative Names: GAPVD1 control peptide, GAPVD1 antibody Blocking Peptide, Anti-GAPVD1 Blocking Peptide, Gtpase Activating Protein And Vps9 Domains 1 Blocking Peptide, DKFZP434C212 Blocking Peptide, KIAA1521 Blocking Peptide, MGC138847 Blocking Peptide, MGC138848 Blocking Peptide, RAP6 Blocking Peptide
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
- Synonyms
- zgc:92666 Peptide, GAPEX5 Peptide, RAP6 Peptide, 2010005B09Rik Peptide, 4432404J10Rik Peptide, AW108497 Peptide, Gapex-5 Peptide, RME-6 Peptide, mKIAA1521 Peptide, RGD1307479 Peptide, GTPase activating protein and VPS9 domains 1 Peptide, GTPase activating protein and VPS9 domains 1 S homeolog Peptide, LOAG_00609 Peptide, GAPVD1 Peptide, gapvd1 Peptide, gapvd1.S Peptide, Gapvd1 Peptide
- Background
- GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
- Molecular Weight
- 166 kDa
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