Norrie Disease (Pseudoglioma) (NDP) Peptide
NDP
Reactivity: Mammalian
Host: Synthetic
BP, IHC, WB
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- Target See all Norrie Disease (Pseudoglioma) (NDP) products
- Norrie Disease (Pseudoglioma) (NDP)
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Sequence
- DPRRCMRHHY VDSISHPLYK CSSKMVLLAR CEGHCSQASR SEPLVSFSTV
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of NDP antibody,
Alternative Names: NDP control peptide, NDP antibody Blocking Peptide, Anti-NDP Blocking Peptide, Norrie Disease Blocking Peptide, Pseudoglioma Blocking Peptide, EVR2 Blocking Peptide, FEVR Blocking Peptide, ND Blocking Peptide - Purification
- Rabbit Anti-p44/42 MAP Kinase (Ab-202) Polyclonal Antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- Norrie Disease (Pseudoglioma) (NDP)
- Synonyms
- EVR2 Peptide, FEVR Peptide, ND Peptide, evr2 Peptide, fevr Peptide, xnorrin Peptide, Ndph Peptide, RGD1563968 Peptide, NDP, norrin cystine knot growth factor Peptide, Norrie disease (pseudoglioma) L homeolog Peptide, Norrie disease (pseudoglioma) (human) Peptide, NDP Peptide, ndp.L Peptide, Ndp Peptide
- Background
- NDP activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. NDP plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. NDP acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1).
- Molecular Weight
- 15 kDa
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