Shugoshin 1 (SGOL1) (C-Term) Peptide
SGOL1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Shugoshin (SGOL1) products
- Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KIRRLSLSPK KNKASPAVAL PKRRCTASVN YKEPTLASKL RRGDPFTDLC
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- SGOL1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
- Synonyms
- sgo1 Peptide, NY-BR-85 Peptide, SGO Peptide, Sgo1 Peptide, 3300001M08Rik Peptide, C81037 Peptide, shugoshin 1 Peptide, shugoshin centromeric cohesion 1 Peptide, shugoshin 1 L homeolog Peptide, Sgo1 Peptide, sgo1 Peptide, sgo1.L Peptide, SGO1 Peptide
- Background
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The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles. Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life. Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
Alias Symbols: SGO, CAID, SGOL1, NY-BR-85
Protein Size: 309 - Gene ID
- 151648
- NCBI Accession
- NM_001012409, NP_001012409
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