Presenilin 1 (PSEN1) (N-Term) Peptide
PSEN1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Presenilin 1 (PSEN1) products
- Presenilin 1 (PSEN1)
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GNSRQVVEQD EEEDEELTLK YGAKHVIMLF VPVTLCMVVV VATIKSVSFY
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- PSEN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Presenilin 1 (PSEN1)
- Background
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Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Alias Symbols: AD3, FAD, PS1, PS-1, S182
Protein Size: 467 - Gene ID
- 5663
- NCBI Accession
- NM_000021, NP_000012
- UniProt
- P49768
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