Tyrosine Kinase 2 (TYK2) (C-Term) Peptide
-
- Target See all TYK2 products
- TYK2 (Tyrosine Kinase 2 (TYK2))
- Protein Region
- C-Term
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LAKAVPEGHE YYRVREDGDS PVFWYAPECL KEYKFYYASD VWSFGVTLYE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- TYK2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- TYK2 (Tyrosine Kinase 2 (TYK2))
- Synonyms
- JTK1 Peptide, tyrosine kinase 2 Peptide, TYK2 Peptide, Tyk2 Peptide
- Background
-
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Alias Symbols: JTK1, IMD35
Protein Size: 1187 - Gene ID
- 7297
- NCBI Accession
- NM_003331, NP_003322
- UniProt
- P29597
-