Ewing Sarcoma Breakpoint Region 1 (EWSR1) (Middle Region) Peptide
EWSR1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all EWSR1 products
- EWSR1 (Ewing Sarcoma Breakpoint Region 1 (EWSR1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- QSSFRQDHPS SMGVYGQESG GFSGPGENRS MSGPDNRGRG RGGFDRGGMS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- EWSR1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- EWSR1 (Ewing Sarcoma Breakpoint Region 1 (EWSR1))
- Background
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This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11,22)(q24,q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
Alias Symbols: EWS, EWS-FLI1, bK984G1.4
Protein Size: 354 - Gene ID
- 2130
- NCBI Accession
- NM_001163285, NP_001156757
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