Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (Middle Region) Peptide
FOLH1
Reactivity: Human
Host: Synthetic
WB
-
- Target See all PSMA (FOLH1) products
- PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
- Protein Region
- Middle Region
- Origin
- Human
-
Source
- Synthetic
- Application
- Western Blotting (WB)
- Sequence
- AQLAGAKGVI LYSDPADYFA PGVKSYPDGW NLPGGGVQRG NILNLNGAGD
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
- Background
-
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
Alias Symbols: PSM, FGCP, FOLH, GCP2, PSMA, mGCP, GCPII, NAALAD1, NAALAdase,
Protein Size: 167 - Gene ID
- 2346
- NCBI Accession
- NM_001014986, NP_001014986
- UniProt
- Q04609
-
You are here:
