Cathepsin C (CTSC) (Middle Region) Peptide
CTSC
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CTSC products
- CTSC (Cathepsin C (CTSC))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- NVYVNIAHLK NSQEKYSNRL YKYDHNFVKA INAIQKSWTA TTYMEYETLT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- CTSC Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CTSC (Cathepsin C (CTSC))
- Background
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This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
Alias Symbols: JP, HMS, JPD, PLS, CPPI, DPP1, DPPI, PALS, DPP-I, PDON1
Protein Size: 463 - Gene ID
- 1075
- NCBI Accession
- NM_001114173, NP_001107645
- UniProt
- P53634
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