Calcium Modulating Ligand (CAMLG) (C-Term) Peptide
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- Target See all CAMLG products
- CAMLG (Calcium Modulating Ligand (CAMLG))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LISEKPSQED GNTTEEFDSF RIFRLVGCAL LALGVRAFVC KYLSIFAPFL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CAMLG Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CAMLG (Calcium Modulating Ligand (CAMLG))
- Synonyms
- MGC53900 Peptide, CAML Peptide, AI385748 Peptide, Camlg Peptide, Caml Peptide, calcium modulating ligand L homeolog Peptide, calcium modulating ligand Peptide, camlg.L Peptide, CAMLG Peptide, camlg Peptide, Caml Peptide, Camlg Peptide
- Background
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The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
Alias Symbols: CAMLG,CAML,
Protein Size: 296 - Gene ID
- 819
- NCBI Accession
- NP_001736
- UniProt
- P49069
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