Septin 2 (SEPT2) (C-Term) Peptide
SEPT2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Septin 2 (SEPT2) products
- Septin 2 (SEPT2)
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- THMQDLQEVT QDLHYENFRS ERLKRGGRKV ENEDMNKDQI LLEKEAELRR
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SEPT2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Septin 2 (SEPT2) peptide
SEPT2 Reactivity: Human, Mouse, Rat, Cow Host: Synthetic BP, Imm
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Septin 2 (SEPT2)
- Synonyms
- DIFF6 Peptide, NEDD5 Peptide, Pnutl3 Peptide, hNedd5 Peptide, AW208991 Peptide, Nedd-5 Peptide, Nedd5 Peptide, mKIAA0158 Peptide, Vesp11 Peptide, nedd5 Peptide, wu:fb52g01 Peptide, wu:fb99a01 Peptide, Septin-2A Peptide, Septin-A Peptide, diff6 Peptide, pnutl3 Peptide, sept2 Peptide, septa Peptide, xlsepta Peptide, SEPT2 Peptide, Sep-02 Peptide, Septin-2B Peptide, hnedd5 Peptide, sept2-B Peptide, Septin-2 Peptide, septin 2 Peptide, septin 2 L homeolog Peptide, septin 2-like Peptide, COG1487; VapC; putative nucleic acid-binding protein; contains PIN domain Peptide, septin 2 S homeolog Peptide, SEPT2 Peptide, Sept2 Peptide, sept2 Peptide, sept2.L Peptide, SEPT2L Peptide, sepT2 Peptide, sept2.S Peptide
- Background
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SEPT2 is a filament-forming cytoskeletal GTPase. It is required for normal organization of the actin cytoskeleton. It plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. It plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. It may play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
Alias Symbols: SEPT2,DIFF6,KIAA0158,NEDD5,
Protein Size: 361 - Gene ID
- 4735
- NCBI Accession
- XP_006712612
- UniProt
- Q15019
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