Caspase 3 (CASP3) (Middle Region) Peptide
CASP3
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all Caspase 3 (CASP3) products
- Caspase 3 (CASP3)
- Protein Region
- Middle Region
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LTGKPKLFII QACRGTELDC GIETDSGTDE EMACQKIPVE ADFLYAYSTA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Casp3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Caspase 3 (CASP3)
- Synonyms
- CPP32 Peptide, CPP32B Peptide, SCA-1 Peptide, A830040C14Rik Peptide, AC-3 Peptide, Apopain Peptide, CC3 Peptide, Caspase-3 Peptide, Lice Peptide, Yama Peptide, mldy Peptide, xcpp32 Peptide, casp3 Peptide, zgc:100890 Peptide, CASP-3 Peptide, caspase-3 Peptide, caspase 3 Peptide, caspase 3 S homeolog Peptide, caspase 3, apoptosis-related cysteine peptidase a Peptide, caspase 3, apoptosis-related cysteine peptidase Peptide, CASP3 Peptide, Casp3 Peptide, casp3.S Peptide, casp3a Peptide
- Background
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Casp3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond, cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain, cleaves and activates caspase-6, -7 and -9, triggers cell adhesion in sympathetic neurons through RET cleavage, cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Alias Symbols: A830040C14Rik, AC-3, Apopain, CC3, CPP32, Caspase-3, Lice, Yama, mldy
Protein Size: 277 - Molecular Weight
- 31 kDa
- Gene ID
- 12367
- NCBI Accession
- NM_009810, NP_033940
- UniProt
- P70677
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