Unc-51 Like Kinase 1 (ULK1) (N-Term) Peptide
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- Target See all ULK1 products
- ULK1 (Unc-51 Like Kinase 1 (ULK1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PEVIMSQHYD GKADLWSIGT IVYQCLTGKA PFQASSPQDL RLFYEKNKTL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ULK1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ULK1 (Unc-51 Like Kinase 1 (ULK1))
- Synonyms
- ATG1 Peptide, ATG1A Peptide, UNC51 Peptide, Unc51.1 Peptide, hATG1 Peptide, si:dkey-11o18.7 Peptide, ulk1 Peptide, ULK1 Peptide, AU041434 Peptide, mKIAA0722 Peptide, zgc:195008 Peptide, unc-51 like autophagy activating kinase 1 Peptide, unc-51 like kinase 1 Peptide, unc-51 like autophagy activating kinase 1a Peptide, ULK1 Peptide, Ulk1 Peptide, ulk1b Peptide, ulk1a Peptide
- Background
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ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.
Alias Symbols: ATG1, ATG1A, UNC51, Unc51.1, hATG1
Protein Size: 1050 - Molecular Weight
- 112 kDa
- Gene ID
- 8408
- NCBI Accession
- NM_003565, NP_003556
- UniProt
- O75385
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