SARS-CoV-2 Spike (C-Term) Peptide
(2 references)-
- Target See all SARS-CoV-2 Spike products
- SARS-CoV-2 Spike
- Protein Region
- C-Term
- Origin
- SARS Coronavirus-2 (SARS-CoV-2), SARS Coronavirus (SARS-CoV)
- Application
- Blocking Peptide (BP)
- Characteristics
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20 amino acids near the carboxy terminus of SARS Spike protein.
Virus
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SARS-CoV-2 Spike peptide
Reactivity: SARS Coronavirus-2 (SARS-CoV-2) Host: Synthetic InhA
SARS-CoV-2 Spike peptideReactivity: SARS Coronavirus-2 (SARS-CoV-2) Host: Synthetic InhA
SARS-CoV-2 Spike peptide (Cy5)Reactivity: SARS Coronavirus-2 (SARS-CoV-2) Host: Synthetic InhA
SARS-CoV-2 Spike peptide (Cy5)Reactivity: SARS Coronavirus-2 (SARS-CoV-2) Host: Synthetic InhA
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- Application Notes
- SARS Spike peptide is used for blocking the activity of the SARS Spike.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 200 μg/mL
- Buffer
- PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1 % bovine serum albumin and 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Expiry Date
- 12 months
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: "High-throughput fabrication of high aspect ratio Ag/Al nanopillars for optical detection of biomarkers." in: Journal of materials chemistry. B, (2021) (PubMed).
: "Detection of antibodies against SARS-CoV-2 spike protein by gold nanospikes in an opto-microfluidic chip." in: Biosensors & bioelectronics, Vol. 169, pp. 112578, (2020) (PubMed).
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: "High-throughput fabrication of high aspect ratio Ag/Al nanopillars for optical detection of biomarkers." in: Journal of materials chemistry. B, (2021) (PubMed).
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- Target
- SARS-CoV-2 Spike
- Synonyms
- E2 Peptide, E2 glycoprotein precursor Peptide, Surface Glycoprotein Peptide, S Peptide
- Target Type
- Viral Protein
- Background
- Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak. The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection. The spike protein is the major target for neutralizing antibodies and vaccine development. The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19. The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein .
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