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Perforin 1 Products

(Perforin 1 (Pore Forming Protein) (PRF1))

Categories

The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].

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Featured Perforin 1 Categories

Perforin 1 Antibodies

High quality antibodies with extensive validation data.

Perforin 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Perforin 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Perforin 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN3020642
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Human
Application FACS, IP, ICC, IHC (fro), IHC (p)
Validations
  • (4)
  • (3)
Cat. No. ABIN1981903
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7254750
Quantity 200 μL
Datasheet Datasheet

Recommended Perforin 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6958461
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962209
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6999555
Quantity 96 tests
Datasheet Datasheet

Recommended Perforin 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1316183
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316185
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7411972
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Perforin 1 products

Li, Jeong, Song: "Molecular Characteristics and Distribution of Adult Human Corneal Immune Cell Types." in: , Vol. 13, pp. 798346, (2022) (PubMed).

Wang, Sun, Wang, Li, Zhao, Zhang, Jin, Tian, Liu, Shi, Tian, Zhang: "The immunoregulatory effects of CD8 T-cell-derived perforin on diet-induced nonalcoholic steatohepatitis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 7, pp. 8490-8503, (2020) (PubMed).

Hu, Valentin, Cai, Dayton, Rosati, Ramírez-Salazar, Kulkarni, Broderick, Sardesai, Wyatt, Earl, Moss, Mullins, Pavlakis, Felber: "DNA Vaccine-Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination." in: Human gene therapy, Vol. 29, Issue 9, pp. 1029-1043, (2019) (PubMed).

Long, Gao, Hu, Xiang, Wu, Zhang, Han, Yin, Qin, Lan, Yin, Wang: "Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma." in: Cancer medicine, Vol. 7, Issue 9, pp. 4690-4700, (2018) (PubMed).

Zhang, Xu, Zhang, Song, Wang, Zhang: "Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells." in: Toxicology and applied pharmacology, Vol. 313, pp. 1-9, (2017) (PubMed).

Parrot, Allard, Oger, Benlalam, Raingeard de la Blétière, Coutolleau, Preisser, Desfrançois, Khammari, Dréno, Labarrière, Delneste, Guardiola, Gervois: "IL-9 promotes the survival and function of human melanoma-infiltrating CD4(+) CD8(+) double-positive T cells." in: European journal of immunology, Vol. 46, Issue 7, pp. 1770-82, (2017) (PubMed).

Rout: "Enhanced Th1/Th17 Functions of CD161+ CD8+ T Cells in Mucosal Tissues of Rhesus Macaques." in: PLoS ONE, Vol. 11, Issue 6, pp. e0157407, (2017) (PubMed).

Sarkar, Mitra, Pant, Kotwal, Kakati, Masih, Sindhwani, Biswas: "Granzyme B as a diagnostic marker of tuberculosis in patients with and without HIV coinfection." in: Diagnostic microbiology and infectious disease, Vol. 85, Issue 1, pp. 47-52, (2016) (PubMed).

Van den Bergh, Willemen, Lion, Van Acker, De Reu, Anguille, Goossens, Berneman, Van Tendeloo, Smits: "Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity." in: Oncotarget, Vol. 6, Issue 42, pp. 44123-33, (2016) (PubMed).

Rah, Kwak, Chung, Kim: "ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells." in: Scientific reports, Vol. 5, pp. 9482, (2015) (PubMed).

Synonyms and alternative names related to Perforin 1

perforin 1 (PRF1), perforin 1 (pore forming protein) (Prf1), perforin 1 (Prf1), perforin (LOC443187), perforin (prf1), perforin 1 L homeolog (prf1.L), Cyta, cytolysin, FLH2, HPLH2, LOC443187, P1, perforin, perforin-1, perforin-1-like, Pfn, PFN1, PFP, Pfp, Prf-1, PRF1, prf1, RATCYTA

Protein level used designations for Perforin 1

  • cytolysin
  • lymphocyte pore forming protein
  • lymphocyte pore-forming protein
  • perforin-1
  • perforin 1 (pore forming protein)
  • perforin-1-like
  • P1
  • pore forming protein
  • perforin
  • perforin 1 (pore forming protein) L homeolog
  • perforin 1 L homeolog
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