Perforin 1 Products
(Perforin 1 (Pore Forming Protein) (PRF1))
Categories
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
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Featured Perforin 1 Categories
Perforin 1 Antibodies
High quality antibodies with extensive validation data.
Perforin 1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Perforin 1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Perforin 1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN3020642
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Human
Application
FACS, IP, ICC, IHC (fro), IHC (p)
Validations
- (4)
- (3)
Cat. No.
ABIN1981903
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN7254750
Quantity
200 μL
Datasheet
Datasheet
Recommended Perforin 1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958461
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962209
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6999555
Quantity
96 tests
Datasheet
Datasheet
Recommended Perforin 1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1316183
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316185
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7411972
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Perforin 1 products
: "Molecular Characteristics and Distribution of Adult Human Corneal Immune Cell Types." in: , Vol. 13, pp. 798346, (2022) (PubMed).: "The immunoregulatory effects of CD8 T-cell-derived perforin on diet-induced nonalcoholic steatohepatitis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 7, pp. 8490-8503, (2020) (PubMed).
: "DNA Vaccine-Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination." in: Human gene therapy, Vol. 29, Issue 9, pp. 1029-1043, (2019) (PubMed).
: "Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma." in: Cancer medicine, Vol. 7, Issue 9, pp. 4690-4700, (2018) (PubMed).
: "Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells." in: Toxicology and applied pharmacology, Vol. 313, pp. 1-9, (2017) (PubMed).
: "IL-9 promotes the survival and function of human melanoma-infiltrating CD4(+) CD8(+) double-positive T cells." in: European journal of immunology, Vol. 46, Issue 7, pp. 1770-82, (2017) (PubMed).
: "Enhanced Th1/Th17 Functions of CD161+ CD8+ T Cells in Mucosal Tissues of Rhesus Macaques." in: PLoS ONE, Vol. 11, Issue 6, pp. e0157407, (2017) (PubMed).
: "Granzyme B as a diagnostic marker of tuberculosis in patients with and without HIV coinfection." in: Diagnostic microbiology and infectious disease, Vol. 85, Issue 1, pp. 47-52, (2016) (PubMed).
: "Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity." in: Oncotarget, Vol. 6, Issue 42, pp. 44123-33, (2016) (PubMed).
: "ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells." in: Scientific reports, Vol. 5, pp. 9482, (2015) (PubMed).
Synonyms and alternative names related to Perforin 1
perforin 1 (PRF1), perforin 1 (pore forming protein) (Prf1), perforin 1 (Prf1), perforin (LOC443187), perforin (prf1), perforin 1 L homeolog (prf1.L), Cyta, cytolysin, FLH2, HPLH2, LOC443187, P1, perforin, perforin-1, perforin-1-like, Pfn, PFN1, PFP, Pfp, Prf-1, PRF1, prf1, RATCYTAProtein level used designations for Perforin 1
- cytolysin
- lymphocyte pore forming protein
- lymphocyte pore-forming protein
- perforin-1
- perforin 1 (pore forming protein)
- perforin-1-like
- P1
- pore forming protein
- perforin
- perforin 1 (pore forming protein) L homeolog
- perforin 1 L homeolog
Did you look for something else?
- PER3
- PER2
- PER1
- Peptidylprolyl Isomerase A (Cyclophilin A)
- Peptidylprolyl Isomerase
- Peptidylglycine alpha-Amidating Monooxygenase
- Peptidylarginine Deiminase
- Peptidoglycan
- Peptide YY, 2 (Pseudogene)
- Peptide YY
- Peptide Histidine-Methionine
- Peptide F
- Peptidase E
- Peptidase B
- Pepsinogen A
- Pepsin A
- Pepsin
- PEPPI
- PEPD
- PEPCK
- Periaxin
- Period Homolog 1 (Drosophila)
- Periostin
- Peripheral Myelin Protein 22
- Peripherin
- PERK
- Permeability Glycoprotein
- Peropsin
- Peroxidase
- Peroxidase 3
- Peroxidase 66
- Peroxidase 70
- Peroxidasin
- Peroxiredoxin
- Peroxiredoxin (tsaA)
- Peroxiredoxin 1
- Peroxiredoxin 2
- Peroxiredoxin 3
- Peroxiredoxin 4
- Peroxiredoxin 5
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