PEN2 Products
(Presenilin Enhancer 2 Homolog (PSENEN))
Categories
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq, Jul 2008].
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Featured PEN2 Categories
PEN2 Antibodies
High quality antibodies with extensive validation data.
PEN2 ELISA Kits
Reliable ELISA kits for a wide range of species.
PEN2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PEN2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN1387540
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7139851
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN565943
Quantity
100 μg
Datasheet
Datasheet
Recommended PEN2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6231793
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN6200572
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN6200571
Quantity
96 tests
Datasheet
Datasheet
Recommended PEN2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316522
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3107691
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3128357
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PEN2 products
: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 7850-4, (2003) (PubMed).
: "Membrane topology of gamma-secretase component PEN-2." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 20117-23, (2003) (PubMed).
: "The role of presenilin cofactors in the gamma-secretase complex." in: Nature, Vol. 422, Issue 6930, pp. 438-41, (2003) (PubMed).
: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).
: "aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation." in: Developmental cell, Vol. 3, Issue 1, pp. 85-97, (2002) (PubMed).
Synonyms and alternative names related to PEN2
presenilin enhancer gamma-secretase subunit (PSENEN), presenilin enhancer 2 (PEN2), presenilin enhancer 2 (Psenen), presenilin enhancer gamma secretase subunit (Psenen), Gamma-secretase subunit pen-2 (pen-2), presenilin enhancer (pen-2), presenilin enhancer gamma secretase subunit S homeolog (psenen.S), presenilin enhancer gamma secretase subunit (psenen), presenilin enhancer gamma-secretase subunit (Psenen), 1700023M09Rik, ACYPI006208, anon-AE003800.1, CG33198, Dmel\\CG33198, dPen-2, MSTP064, PEN-2, Pen-2, pen-2, PEN2, pen2, Psenen, psenen, RGD1312037, zgc:109727Protein level used designations for PEN2
- gamma-secretase subunit PEN-2
- hematopoietic stem/progenitor cells protein MDS033
- presenilin enhancer protein 2
- presenilin enhancer 2
- LRRGT00140 mRNA
- liver regeneration-related protein LRRGT00140
- CG33198-PA
- pen-2-PA
- presenilin enhancer 2 homolog
- presenilin enhancer gamma secretase subunit S homeolog
- Presenilin enhancer protein 2 homolog
- presenilin enhancer protein 2 homolog
Did you look for something else?
- PEMT
- PELP1
- PELO
- Pellino 3
- Pellino 1
- PELI2
- PELE
- PELB
- PELA
- Pejvakin
- PEG3
- PEG10
- PEG
- PEF1
- PEDF
- PECR
- PECI/ECI2
- PEBP4
- PEBP1
- PEBB
- Penicillin
- Penicillin G
- Penicillinase
- pepA
- PEPCK
- PEPD
- PEPPI
- Pepsin
- Pepsin A
- Pepsinogen A
- Peptidase B
- Peptidase E
- Peptide F
- Peptide Histidine-Methionine
- Peptide YY
- Peptide YY, 2 (Pseudogene)
- Peptidoglycan
- Peptidylarginine Deiminase
- Peptidylglycine alpha-Amidating Monooxygenase
- Peptidylprolyl Isomerase
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