PDK4 Products
(Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))
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This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008].
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Featured PDK4 Categories
PDK4 Antibodies
High quality antibodies with extensive validation data.
PDK4 ELISA Kits
Reliable ELISA kits for a wide range of species.
PDK4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PDK4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, IHC (p)
Validations
- (24)
- (6)
Cat. No.
ABIN391039
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7439630
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF, mIHC
Validations
- (1)
- (7)
Cat. No.
ABIN3028963
Quantity
0.2 mL
Datasheet
Datasheet
Recommended PDK4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969802
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953337
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
Cat. No.
ABIN1116875
Quantity
96 tests
Datasheet
Datasheet
Recommended PDK4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124722
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314558
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314556
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PDK4 products
: "Immune Checkpoint Blockade Improves Chemotherapy in the PyMT Mammary Carcinoma Mouse Model." in: Frontiers in oncology, Vol. 10, pp. 1771, (2020) (PubMed).: "High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases." in: British journal of cancer, Vol. 120, Issue 7, pp. 675-688, (2019) (PubMed).
: "Overexpression of lncRNA EPB41L4A-AS1 Induces Metabolic Reprogramming in Trophoblast Cells and Placenta Tissue of Miscarriage." in: Molecular therapy. Nucleic acids, Vol. 18, pp. 518-532, (2019) (PubMed).
: "Defining the contribution of skeletal muscle pyruvate dehydrogenase alpha 1 (Pdha1) to exercise performance and insulin action." in: American journal of physiology. Endocrinology and metabolism, (2018) (PubMed).
: "The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes." in: Clinical and translational medicine, Vol. 6, Issue 1, pp. 5, (2017) (PubMed).
: "On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 8, pp. 2684-97, (2017) (PubMed).
: "Arsenic silences hepatic PDK4 expression through activation of histone H3K9 methylatransferase G9a." in: Toxicology and applied pharmacology, Vol. 304, pp. 42-7, (2017) (PubMed).
: "Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer." in: The Journal of biological chemistry, Vol. 291, Issue 33, pp. 17405-16, (2017) (PubMed).
: "The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis." in: Oncogene, Vol. 36, Issue 7, pp. 989-998, (2017) (PubMed).
: "Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells." in: Oncogene, Vol. 36, Issue 44, pp. 6164-6176, (2017) (PubMed).
Synonyms and alternative names related to PDK4
pyruvate dehydrogenase kinase 4 (pdk4), pyruvate dehydrogenase kinase 4 (PDK4), pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4), pyruvate dehydrogenase kinase 4 (Pdk4), AV005916Protein level used designations for PDK4
- pyruvate dehydrogenase kinase 4
- pyruvate dehydrogenase kinase, isoenzyme 4
- pyruvate dehydrogenase kinase, isozyme 4
- [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
- pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
- pyruvate dehydrogenase kinase isozyme 4
- pyruvate dehydrogenate kinase 4
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