Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PDK3 Products

(Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3))

Categories

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured PDK3 Categories

PDK3 Antibodies

High quality antibodies with extensive validation data.

PDK3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PDK3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
  • (4)
Cat. No. ABIN562161
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
  • (2)
Cat. No. ABIN391038
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS
Validations
  • (1)
  • (2)
Cat. No. ABIN652286
Quantity 400 μL
Datasheet Datasheet

Recommended PDK3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6206626
Quantity 96 tests
Datasheet Datasheet

Recommended PDK3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314554
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314553
Quantity 25 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7417198
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PDK3 products

Hou, Zhang, Han, Ge, Ma, Zhang, Moley, Schedl, Wang: "Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation." in: Journal of cell science, Vol. 128, Issue 13, pp. 2319-29, (2015) (PubMed).

Ho, Coomber: "Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells." in: Experimental cell research, Vol. 331, Issue 1, pp. 73-81, (2015) (PubMed).

Shimura, Nakai, Jiao, Osanai, Kashikura, Endo, Soga, Goda, Minamisawa: "Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 305, Issue 4, pp. H494-505, (2013) (PubMed).

Hwang, Wu, Harris: "Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet." in: The FEBS journal, Vol. 279, Issue 10, pp. 1883-93, (2012) (PubMed).

Halim, Mcfate, Mohyeldin, Okagaki, Korotchkina, Patel, Jeoung, Harris, Schell, Verma: "Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons." in: Glia, Vol. 58, Issue 10, pp. 1168-76, (2010) (PubMed).

Jeoung, Harris: "Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice." in: American journal of physiology. Endocrinology and metabolism, Vol. 295, Issue 1, pp. E46-54, (2008) (PubMed).

Lu, Lin, Chen, Lai, Tsai: "Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28106-14, (2008) (PubMed).

McFate, Mohyeldin, Lu, Thakar, Henriques, Halim, Wu, Schell, Tsang, Teahan, Zhou, Califano, Jeoung, Harris, Verma: "Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells." in: The Journal of biological chemistry, Vol. 283, Issue 33, pp. 22700-8, (2008) (PubMed).

Xu, Han, Epstein, Liu: "Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets." in: Biochemical and biophysical research communications, Vol. 344, Issue 3, pp. 827-33, (2006) (PubMed).

Synonyms and alternative names related to PDK3

pyruvate dehydrogenase kinase 3 (PDK3), pyruvate dehydrogenase kinase 3 (Pdk3), pyruvate dehydrogenase kinase, isozyme 3a (pdk3a), pyruvate dehydrogenase kinase 3 (pdk3), pyruvate dehydrogenase kinase, isoenzyme 3 (Pdk3), fragile site, 5-azacytidine type, common, fra(1)(q12) (FRA1J), pyruvate dehydrogenase kinase, isozyme 3b (pdk3b), 2610001M10Rik, AI035637, pdk3, PDK3, zgc:158702

Protein level used designations for PDK3

  • pyruvate dehydrogenase kinase, isoenzyme 3
  • pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
  • Pyruvate dehydrogenase kinase 3
  • [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
  • pyruvate dehydrogenase kinase 3
  • pyruvate dehydrogenase kinase, isozyme 3
  • pyruvate dehydrogenase [lipoamide] kinase isozyme 3, mitochondrial-like
  • pyruvate dehydrogenase kinase, isozyme 3b
You are here:
Support