PDK3 Products
(Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3))
Categories
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
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Featured PDK3 Categories
PDK3 Antibodies
High quality antibodies with extensive validation data.
PDK3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PDK3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
- (4)
Cat. No.
ABIN562161
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
- (2)
Cat. No.
ABIN391038
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (1)
- (2)
Cat. No.
ABIN652286
Quantity
400 μL
Datasheet
Datasheet
Recommended PDK3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6206626
Quantity
96 tests
Datasheet
Datasheet
Recommended PDK3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314554
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314553
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7417198
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PDK3 products
: "Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation." in: Journal of cell science, Vol. 128, Issue 13, pp. 2319-29, (2015) (PubMed).: "Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells." in: Experimental cell research, Vol. 331, Issue 1, pp. 73-81, (2015) (PubMed).
: "Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 305, Issue 4, pp. H494-505, (2013) (PubMed).
: "Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet." in: The FEBS journal, Vol. 279, Issue 10, pp. 1883-93, (2012) (PubMed).
: "Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons." in: Glia, Vol. 58, Issue 10, pp. 1168-76, (2010) (PubMed).
: "Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice." in: American journal of physiology. Endocrinology and metabolism, Vol. 295, Issue 1, pp. E46-54, (2008) (PubMed).
: "Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28106-14, (2008) (PubMed).
: "Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells." in: The Journal of biological chemistry, Vol. 283, Issue 33, pp. 22700-8, (2008) (PubMed).
: "Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets." in: Biochemical and biophysical research communications, Vol. 344, Issue 3, pp. 827-33, (2006) (PubMed).
Synonyms and alternative names related to PDK3
pyruvate dehydrogenase kinase 3 (PDK3), pyruvate dehydrogenase kinase 3 (Pdk3), pyruvate dehydrogenase kinase, isozyme 3a (pdk3a), pyruvate dehydrogenase kinase 3 (pdk3), pyruvate dehydrogenase kinase, isoenzyme 3 (Pdk3), fragile site, 5-azacytidine type, common, fra(1)(q12) (FRA1J), pyruvate dehydrogenase kinase, isozyme 3b (pdk3b), 2610001M10Rik, AI035637, pdk3, PDK3, zgc:158702Protein level used designations for PDK3
- pyruvate dehydrogenase kinase, isoenzyme 3
- pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
- Pyruvate dehydrogenase kinase 3
- [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
- pyruvate dehydrogenase kinase 3
- pyruvate dehydrogenase kinase, isozyme 3
- pyruvate dehydrogenase [lipoamide] kinase isozyme 3, mitochondrial-like
- pyruvate dehydrogenase kinase, isozyme 3b
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