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PDHX Proteins

(Pyruvate Dehydrogenase Complex, Component X (PDHX))

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].

recommended

PDHX Protein (AA 1-109) (GST tag) (ABIN1314527)

PDHX Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

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recommended

PDHX Protein (AA 54-501) (His tag) (ABIN7124721)

PDHX Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

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recommended

PDHX Protein (AA 220-468) (His tag) (ABIN7416460)

PDHX Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, Imm, PC

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PDHX Proteins by Origin

Find PDHX Proteins for a variety of species such as anti-Human PDHX, anti-Cow PDHX, anti-Mouse PDHX. The species listed below are among those available. Click on a link to go to the corresponding products.

PDHX Proteins by Source

Here you will find PDHX Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PDHX Proteins by Protein Type

Here you can find PDHX Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

PDHX Proteins by Application

Find PDHX Proteins validated for a specific application such as WB, ELISA, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular PDHX Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

PDHX Protein (AA 1-109) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1314527

Quantity 10 μg

Datasheet Datasheet

PDHX Protein (AA 54-501) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7124721

Quantity 50 μg

Datasheet Datasheet

PDHX Protein (AA 220-468) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7416460

Quantity 100 μg

Datasheet Datasheet

PDHX Protein (AA 222-471) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7416508

Quantity 100 μg

Datasheet Datasheet

PDHX Protein (AA 54-500) (His tag)

Reactivity Pig

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7424446

Quantity 100 μg

Datasheet Datasheet

PDHX Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2728549

Quantity 20 μg

Datasheet Datasheet

PDHX Protein (AA 54-501) (His tag)

Reactivity Cow

Source Yeast

Validations

Cat. No. ABIN1459716

Quantity 1 mg

Datasheet Datasheet

Aliases for PDHX Proteins

pyruvate dehydrogenase complex component X (PDHX) Proteins
pyruvate dehydrogenase complex, component X (Pdhx) Proteins
pyruvate dehydrogenase complex, component X (pdhx) Proteins
pyruvate dehydrogenase complex component X L homeolog (pdhx.L) Proteins
E3-binding protein (pdhX) Proteins
pyruvate dehydrogenase complex component X (pdhx) Proteins
Ac1164 Proteins
AI481367 Proteins
DDBDRAFT_0168431 Proteins
DDBDRAFT_0230192 Proteins
DDB_0168431 Proteins
DDB_0230192 Proteins
DLDBP Proteins
E3BP Proteins
E3bp Proteins
MGC86218 Proteins
OPDX Proteins
PDHX Proteins
PDX1 Proteins
Pdx1 Proteins
proX Proteins
zgc:66110 Proteins
zgc:85977 Proteins

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PDHX Proteins by Origin

PDHX Proteins by Source

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Popular PDHX Proteins

Aliases for PDHX Proteins

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