PDE6A Products
(phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))
Categories
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008].
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Featured PDE6A Categories
PDE6A Antibodies
High quality antibodies with extensive validation data.
PDE6A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PDE6A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7168417
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7168416
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (1)
Cat. No.
ABIN6264095
Quantity
100 μL
Datasheet
Datasheet
Recommended PDE6A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6220832
Quantity
96 tests
Datasheet
Datasheet
Recommended PDE6A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2750993
Quantity
5 applications
Datasheet
Datasheet
Latest Publications for our PDE6A products
: "Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype." in: Human molecular genetics, Vol. 24, Issue 19, pp. 5486-99, (2015) (PubMed).: "Scalable in situ hybridization on tissue arrays for validation of novel cancer and tissue-specific biomarkers." in: PLoS ONE, Vol. 7, Issue 3, pp. e32927, (2012) (PubMed).
: "Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43)." in: Human gene therapy (PubMed).
Synonyms and alternative names related to PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha (pde6a), phosphodiesterase 6A (PDE6A), phosphodiesterase 6A (pde6a), phosphodiesterase 6A, cGMP-specific, rod, alpha (Pde6a), phosphodiesterase 6A (Pde6a), CGPR-A, nmf282, PDEA, Pdea, RP43, si:bz1d10.3, si:rp71-1d10.3Protein level used designations for PDE6A
- cGMP-specific
- rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
- phosphodiesterase 6A, alpha subunit
- phosphodiesterase 6A, cGMP-specific, rod, alpha
- phosphodiesterase 6A-like
- rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha-like
- GMP-PDE alpha
- PDE V-B1
- phosphodiesterase, cyclic GMP (rod receptor), alpha polypeptide
- cGMP phosphodiesterase alpha subunit
- rod photoreceptor cGMP phosphodiesterase alpha subunit
- cGMP phosphodiesterase alpha
- cGMP-phosphodiesterase alpha-subunit
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