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PDE4A Products

(phosphodiesterase 4A, CAMP-Specific (PDE4A))

Categories

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

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Featured PDE4A Categories

PDE4A Antibodies

High quality antibodies with extensive validation data.

PDE4A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PDE4A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF, FACS, IHC (p)
Validations
  • (7)
Cat. No. ABIN1500089
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7243706
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7269302
Quantity 100 μL
Datasheet Datasheet

Recommended PDE4A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6231741
Quantity 96 tests
Datasheet Datasheet

Recommended PDE4A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314462
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2728507
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094538
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PDE4A products

Ale-Agha, Goy, Jakobs, Spyridopoulos, Gonnissen, Dyballa-Rukes, Aufenvenne, von Ameln, Zurek, Spannbrucker, Eckermann, Jakob, Gorressen, Abrams, Grandoch, Fischer, Köhrer, Deenen, Unfried, Altschmied et al.: "CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. ..." in: PLoS biology, Vol. 16, Issue 6, pp. e2004408, (2018) (PubMed).

Lee, Shin, Hong: "The Regulatory Role of Rolipram on Inflammatory Mediators and Cholinergic/Adrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells." in: Mediators of inflammation, Vol. 2016, pp. 3745961, (2017) (PubMed).

Avila, Barker, Zhang, McClain, Barve, Gobejishvili: "Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis." in: The Journal of pathology, Vol. 240, Issue 1, pp. 96-107, (2017) (PubMed).

Taniguchi, Iizumi, Watanabe, Masuda, Morita, Aono, Toriyama, Oishi, Goi, Sakai: "Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer." in: Cell death & disease, Vol. 7, pp. e2211, (2016) (PubMed).

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Kedia, Ückert, Oelke, Sonnenberg, Sohn, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." in: Urology, Vol. 85, Issue 4, pp. 964.e1-6, (2015) (PubMed).

Yougbaré, Boire, Roy, Lugnier, Rouseau: "NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production." in: Canadian journal of physiology and pharmacology, Vol. 91, Issue 5, pp. 353-61, (2014) (PubMed).

Guo, Lin, Zhao, Zhang, Wei, Wang, Wang: "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." in: Neuroscience, Vol. 263, pp. 1-14, (2014) (PubMed).

Zhai, Chang, Wei, Liu, Leblais, Fischmeister, Ji: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." in: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).

Synonyms and alternative names related to PDE4A

phosphodiesterase 4A S homeolog (pde4a.S), phosphodiesterase 4A, cAMP-specific (pde4a), phosphodiesterase 4A (PDE4A), phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) (PDE4A), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (LOC100009247), phosphodiesterase 4A (Pde4a), phosphodiesterase 4A (pde4a), phosphodiesterase 4A, cAMP specific (Pde4a), phosphodiesterase 4C (PDE4C), phosphodiesterase 4A, cAMP-specific (PDE4A), D9Ertd60e, dpde2, Dpde2, DPDE2, pde4, PDE4, PDE4A, Pde4a, pde46, PDE46, PHOSA

Protein level used designations for PDE4A

  • phosphodiesterase 4A, cAMP-specific
  • phosphodiesterase 4A-like
  • phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
  • cyclic AMP-specific phosphodiesterase FCPDE4A1A
  • cyclic AMP-specific phosphodiesterase OCPDE4A1A
  • phosphodiesterase 4A, cAMP specific
  • cyclic AMP-specific phosphodiesterase CPPDE4A1A
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4A
  • cAMP-specific phosphodiesterase PDE4A
  • cyclic AMP specific phosphodiesterase PDE4A5A
  • dunce
  • phosphodiesterase 4A, cAMP-specific (dunce
  • phosphodiesterase E2 dunce homolog, Drosophila
  • phosphodiesterase isozyme 4
  • DPDE2
  • cyclic AMP-specific phosphodiesterase SSPDE4A1A
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