PDE3A Products
(phosphodiesterase 3A, cGMP-Inhibited (PDE3A))
Categories
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
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Featured PDE3A Categories
PDE3A Antibodies
High quality antibodies with extensive validation data.
PDE3A ELISA Kits
Reliable ELISA kits for a wide range of species.
PDE3A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PDE3A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (4)
Cat. No.
ABIN7259753
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
Cat. No.
ABIN518720
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7269301
Quantity
100 μL
Datasheet
Datasheet
Recommended PDE3A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958531
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5674894
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5674895
Quantity
96 tests
Datasheet
Datasheet
Recommended PDE3A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314458
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7408213
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3114834
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PDE3A products
: "Possible mechanisms mediating the protective effect of cilostazol in L-arginine induced acute pancreatitis in rats: role of cGMP, cAMP, and HO-1." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 393, Issue 10, pp. 1859-1870, (2020) (PubMed).: "Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes." in: Cellular signalling, Vol. 28, Issue 7, pp. 725-32, (2017) (PubMed).
: "The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway." in: Science signaling, Vol. 8, Issue 398, pp. ra101, (2016) (PubMed).
: "Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly. ..." in: Hypertension (Dallas, Tex. : 1979), Vol. 66, Issue 4, pp. 800-8, (2015) (PubMed).
: "Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation." in: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 509-18, (2015) (PubMed).
: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).
: "Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle." in: American journal of physiology. Cell physiology, Vol. 307, Issue 4, pp. C402-11, (2014) (PubMed).
: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).
: "Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte." in: Journal of molecular and cellular cardiology, Vol. 52, Issue 2, pp. 388-400, (2012) (PubMed).
: "Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles." in: The journal of sexual medicine, Vol. 8, Issue 11, pp. 3058-65, (2012) (PubMed).
Synonyms and alternative names related to PDE3A
phosphodiesterase 3A (PDE3A), phosphodiesterase 3A, cGMP-inhibited (Pde3a), cGMP-inhibited 3',5'-cyclic phosphodiesterase A (LOC100540515), phosphodiesterase 3A (pde3a), phosphodiesterase 3A, cGMP-inhibited (pde3a), phosphodiesterase 3A, cGMP inhibited (Pde3a), phosphodiesterase 3A (Pde3a), A930022O17Rik, C87899, CGI-PDE, CGI-PDE-A, CGI-PDE A, PDE3A, Pde3a, RNPDE3A, si:dkey-48h7.2Protein level used designations for PDE3A
- phosphodiesterase 3A, cGMP-inhibited
- cGMP-inhibited 3',5'-cyclic phosphodiesterase A
- phosphodiesterase 3a
- cGMP-inhibited 3',5'-cyclic phosphodiesterase A-like
- CGI-PDE A
- cGMP-inhibited phosphodiesterase
- cyclic GMP-inhibited phosphodiesterase A
- cyclic nucleotide phosphodiesterase
- cAMP phosphodiesterase, myocardial cGMP-inhibited
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