PDE10A Products
(phosphodiesterase 10A (PDE10A))
Categories
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011].
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Featured PDE10A Categories
PDE10A Antibodies
High quality antibodies with extensive validation data.
PDE10A ELISA Kits
Reliable ELISA kits for a wide range of species.
PDE10A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PDE10A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (1)
- (3)
Cat. No.
ABIN2728471
Quantity
0.1 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7436099
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, ICC, IF
Validations
- (2)
Cat. No.
ABIN6264085
Quantity
100 μL
Datasheet
Datasheet
Recommended PDE10A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969258
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958527
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN456476
Quantity
96 tests
Datasheet
Datasheet
Recommended PDE10A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314446
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7398554
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136395
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PDE10A products
: "Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa." in: Biochimica et biophysica acta, Vol. 1861, Issue 2, pp. 147-156, (2017) (PubMed).: "Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa." in: PLoS ONE, Vol. 11, Issue 8, pp. e0161035, (2016) (PubMed).
: "Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity." in: Oncogene, Vol. 34, Issue 12, pp. 1499-509, (2015) (PubMed).
: "Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A." in: Nuclear medicine and biology, Vol. 42, Issue 2, pp. 146-54, (2015) (PubMed).
: "Levodopa-induced dyskinesias are associated with transient down-regulation of cAMP and cGMP in the caudate-putamen of hemiparkinsonian rats: reduced synthesis or increased catabolism?" in: Neurochemistry international, Vol. 79, pp. 44-56, (2015) (PubMed).
: "Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions." in: Neuropharmacology, Vol. 76 Pt A, pp. 127-36, (2014) (PubMed).
: "Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures." in: Neuro-Signals, Vol. 21, Issue 3-4, pp. 197-212, (2013) (PubMed).
: "Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling." in: PLoS ONE, Vol. 6, Issue 4, pp. e18136, (2011) (PubMed).
: "PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology." in: Neurobiology of disease, Vol. 43, Issue 1, pp. 293-303, (2011) (PubMed).
: "The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release." in: British journal of pharmacology, Vol. 157, Issue 4, pp. 633-44, (2009) (PubMed).
Synonyms and alternative names related to PDE10A
phosphodiesterase 10A (PDE10A), phosphodiesterase 10A (Pde10a), HSPDE10A, Pde10a3Protein level used designations for PDE10A
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
- dJ416F21.1 (phosphodiesterase 10A)
- phosphodiesterase 10A1 (PDE10A1)
- PDE10A2 brain-specific isoform
- dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase
- testis-specific phosphodiesterase PDE10A2
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