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PCSK1 Products

(Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010].

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Featured PCSK1 Categories

PCSK1 Antibodies

High quality antibodies with extensive validation data.

PCSK1 ELISA Kits

Reliable ELISA kits for a wide range of species.

PCSK1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PCSK1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
  • (7)
Cat. No. ABIN7435748
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7443446
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (8)
Cat. No. ABIN562137
Quantity 100 μg
Datasheet Datasheet

Recommended PCSK1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958849
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958850
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1571753
Quantity 96 tests
Datasheet Datasheet

Recommended PCSK1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314348
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7406851
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
Cat. No. ABIN1989721
Quantity 25 μg
Datasheet Datasheet

Latest Publications for our PCSK1 products

Evans, Rodriguez, Ragolia: "ACTH promotes chondrogenic nodule formation and induces transient elevations in intracellular calcium in rat bone marrow cell cultures via MC2-R signaling." in: Cell and tissue research, Vol. 352, Issue 2, pp. 413-25, (2013) (PubMed).

Evans, Fernando, Ragolia: "Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells." in: Molecular and cellular endocrinology, Vol. 355, Issue 1, pp. 60-70, (2012) (PubMed).

Mbikay, Sirois, Nkongolo, Basak, Chrétien: "Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity." in: Molecular genetics and metabolism, Vol. 104, Issue 4, pp. 682-7, (2011) (PubMed).

Jackson, Creemers, Farooqi, Raffin-Sanson, Varro, Dockray, Holst, Brubaker, Corvol, Polonsky, Ostrega, Becker, Bertagna, Hutton, White, Dattani, Hussain, Middleton, Nicole, Milla, Lindley, ORahilly: "Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency." in: The Journal of clinical investigation, Vol. 112, Issue 10, pp. 1550-60, (2003) (PubMed).

Synonyms and alternative names related to PCSK1

proprotein convertase subtilisin/kexin type 1 (PCSK1), proprotein convertase subtilisin/kexin type 1 (Pcsk1), proprotein convertase subtilisin/kexin type 1 (pcsk1), prohormone convertase 1 (PC1B), BDP, BMIQ12, Nec-1, NEC1, Nec1, PC1, PC1/3, PC3, Phpp-1, SPC3

Protein level used designations for PCSK1

  • NEC 1
  • neuroendocrine convertase 1
  • prohormone convertase 1
  • prohormone convertase 3
  • furin homolog
  • prohormone convertase 1/3
  • propeptide-processing protease
  • proprotein convertase 1
  • Protein convertase subtilisin / kexin type I
  • Protein convertase subtilisin / kexin, type I
  • prohormone convertase
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