PCSK1 Products
(Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
Categories
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010].
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Featured PCSK1 Categories
PCSK1 Antibodies
High quality antibodies with extensive validation data.
PCSK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PCSK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PCSK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (7)
Cat. No.
ABIN7435748
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7443446
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (8)
Cat. No.
ABIN562137
Quantity
100 μg
Datasheet
Datasheet
Recommended PCSK1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958849
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958850
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1571753
Quantity
96 tests
Datasheet
Datasheet
Recommended PCSK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314348
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7406851
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
Cat. No.
ABIN1989721
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our PCSK1 products
: "ACTH promotes chondrogenic nodule formation and induces transient elevations in intracellular calcium in rat bone marrow cell cultures via MC2-R signaling." in: Cell and tissue research, Vol. 352, Issue 2, pp. 413-25, (2013) (PubMed).: "Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells." in: Molecular and cellular endocrinology, Vol. 355, Issue 1, pp. 60-70, (2012) (PubMed).
: "Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity." in: Molecular genetics and metabolism, Vol. 104, Issue 4, pp. 682-7, (2011) (PubMed).
: "Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency." in: The Journal of clinical investigation, Vol. 112, Issue 10, pp. 1550-60, (2003) (PubMed).
Synonyms and alternative names related to PCSK1
proprotein convertase subtilisin/kexin type 1 (PCSK1), proprotein convertase subtilisin/kexin type 1 (Pcsk1), proprotein convertase subtilisin/kexin type 1 (pcsk1), prohormone convertase 1 (PC1B), BDP, BMIQ12, Nec-1, NEC1, Nec1, PC1, PC1/3, PC3, Phpp-1, SPC3Protein level used designations for PCSK1
- NEC 1
- neuroendocrine convertase 1
- prohormone convertase 1
- prohormone convertase 3
- furin homolog
- prohormone convertase 1/3
- propeptide-processing protease
- proprotein convertase 1
- Protein convertase subtilisin / kexin type I
- Protein convertase subtilisin / kexin, type I
- prohormone convertase
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