PBX1 Products
(Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
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This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1\;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
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Featured PBX1 Categories
PBX1 Antibodies
High quality antibodies with extensive validation data.
PBX1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PBX1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PBX1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
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Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (5)
- (5)
Cat. No.
ABIN562114
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC
Validations
- (3)
Cat. No.
ABIN7164137
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
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Validations
- (2)
Cat. No.
ABIN571168
Quantity
100 μg
Datasheet
Datasheet
Recommended PBX1 ELISA Kits
Recommended PBX1 Proteins
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Escherichia coli (E. coli)
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Cat. No.
ABIN7124544
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314106
Quantity
10 μg
Datasheet
Datasheet
Reactivity
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Source
Wheat germ
Validations
Cat. No.
ABIN5954421
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PBX1 products
: "The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1." in: Cell reports, Vol. 14, Issue 5, pp. 1156-1168, (2016) (PubMed).: "Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion." in: Nature communications, Vol. 6, pp. 10044, (2015) (PubMed).
: "Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 19, Issue 8, pp. 1960-71, (2013) (PubMed).
: "Cooperative transcriptional activation by Klf4, Meis2, and Pbx1." in: Molecular and cellular biology, Vol. 31, Issue 18, pp. 3723-33, (2011) (PubMed).
: "PBX1 genomic pioneer function drives ER? signaling underlying progression in breast cancer." in: PLoS genetics, Vol. 7, Issue 11, pp. e1002368, (2011) (PubMed).
: "Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation." in: Human molecular genetics, Vol. 18, Issue 4, pp. 679-87, (2009) (PubMed).
: "Gfi1 integrates progenitor versus granulocytic transcriptional programming." in: Blood, Vol. 113, Issue 22, pp. 5466-75, (2009) (PubMed).
: "Evaluating the association of common PBX1 variants with type 2 diabetes." in: BMC medical genetics, Vol. 9, pp. 14, (2008) (PubMed).
: "Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer." in: Cancer research, Vol. 68, Issue 21, pp. 8852-60, (2008) (PubMed).
: "Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth." in: The American journal of pathology, Vol. 170, Issue 1, pp. 152-9, (2007) (PubMed).
Synonyms and alternative names related to PBX1
PBX homeobox 1 (PBX1), pre-B-cell leukemia homeobox 1a (pbx1a), pre B cell leukemia homeobox 1 (Pbx1), PBX homeobox 1 (Pbx1), pre-B-cell leukemia homeobox 1 S homeolog (pbx1.S), 2310056B04Rik, AI848790, AU015730, D230003C07Rik, fi29e01, Pbx-1, Pbx1a, PBX1A, pbx1b, Pbx1b, wu:fi29e01, Xpbx1, Xpbx1b, zgc:55265Protein level used designations for PBX1
- homeobox protein PBX1
- homeobox protein PRL
- pre-B-cell leukemia transcription factor 1
- pre-B-cell leukemia transcription factor 1b
- pre B-cell leukemia transcription factor 1
- Homeobox protein pbx1
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