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PBK Products

(PDZ Binding Kinase (PBK))

Categories

This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. [provided by RefSeq, Jul 2008].

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Featured PBK Categories

PBK Antibodies

High quality antibodies with extensive validation data.

PBK ELISA Kits

Reliable ELISA kits for a wide range of species.

PBK Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PBK Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS, ICC
Validations
  • (2)
  • (7)
Cat. No. ABIN969345
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (7)
Cat. No. ABIN527757
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p), FACS
Validations
  • (2)
  • (4)
Cat. No. ABIN1881635
Quantity 400 μL
Datasheet Datasheet

Recommended PBK ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380317
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6951206
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1141112
Quantity 96 tests
Datasheet Datasheet

Recommended PBK Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124331
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314100
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314096
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our PBK products

Park, Nishidate, Nakamura, Katagiri: "Critical roles of T-LAK cell-originated protein kinase in cytokinesis." in: Cancer science, Vol. 101, Issue 2, pp. 403-11, (2010) (PubMed).

Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: "Tissue profiling of the mammalian central nervous system using human antibody-based proteomics." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 7, pp. 1612-22, (2009) (PubMed).

Oh, Zhu, Cho, Lee, Kang, Kim, Zykova, Bode, Dong: "T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation." in: Cancer research, Vol. 67, Issue 11, pp. 5186-94, (2007) (PubMed).

Zykova, Zhu, Lu, Higgins, Tatsumi, Abe, Bode, Dong: "Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 23, pp. 6884-93, (2006) (PubMed).

Fujibuchi, Abe, Takeuchi, Ueda, Shigemoto, Yamamoto, Kito: "Expression and phosphorylation of TOPK during spermatogenesis." in: Development, growth & differentiation, Vol. 47, Issue 9, pp. 637-44, (2005) (PubMed).

Nandi, Tidwell, Karp, Rapoport: "Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells." in: Blood cells, molecules & diseases, Vol. 32, Issue 1, pp. 240-5, (2004) (PubMed).

Simons-Evelyn, Bailey-Dell, Toretsky, Ross, Fenton, Kalvakolanu, Rapoport: "PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells." in: Blood cells, molecules & diseases, Vol. 27, Issue 5, pp. 825-9, (2002) (PubMed).

Zhao, Dai, Zhao, Xia, Zhou, Wang, Gu, Ying, Xie, Mao: "PDZ-binding kinase participates in spermatogenesis." in: The international journal of biochemistry & cell biology, Vol. 33, Issue 6, pp. 631-6, (2001) (PubMed).

Abe, Matsumoto, Kito, Ueda: "Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21525-31, (2000) (PubMed).

Gaudet, Branton, Lue: "Characterization of PDZ-binding kinase, a mitotic kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 10, pp. 5167-72, (2000) (PubMed).

Synonyms and alternative names related to PBK

PDZ binding kinase (PBK), PDZ binding kinase (pbk), PDZ binding kinase (Pbk), PDZ binding kinase L homeolog (pbk.L), 2810434B10Rik, AW538537, CT84, D14Ertd732e, Nori-3, PBK, SPK, topk, TOPK, zgc:92050

Protein level used designations for PBK

  • PDZ binding kinase
  • T-LAK cell-originated protein kinase
  • MAPKK-like protein kinase
  • cancer/testis antigen 84
  • lymphokine-activated killer T-cell-originated protein kinase
  • serine/threonine protein kinase
  • spermatogenesis-related protein kinase
  • PDZ-binding kinase
  • PBK, PDZ-binding kinase
  • lymphokine-activated killer T-cell-originated protein kinase homolog
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