CD8 FITC - CD28 PE Bi-Test Reagent
FACS
Reactivity: Human
FACS
FITC,PE
Host: Mouse
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- Target
- CD8, CD28
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- FITC,PE
- Application
- Flow Cytometry (FACS)
- Brand
- Bi-Test™
- Purification
- Protein A/G Chromatography
- Isotype
- IgG1
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- Restrictions
- For Research Use only
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- Storage
- 4 °C
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- Target
- CD8, CD28
- Background
- Identification of human cytotoxic/suppressor T cells expressing the 32 and 43,000 M.W. surface antigen. CD38 antigen is an integral membrane glycoprotein, M.W. 45 kD. Anti-human CD28 binds the 44 kDa MW cell surface protein on the surface of most T cells. CD28 acts as the ligand for the B7/BB-1 Molecule on the surface of activated B cells. B7/BB-1 co-stimulates T cells through CD28, along with CD2 and CD3. CD28 antigen is a disulfide-linked homodimeric glycoprotein. The CD28 antigen is present on approximately 60 % -80 % T lymphocytes (95 % of CD4 and 50 % of CD8 lymphocytes). CD28 regulates the expression of cytokines by T cells, not only IL-2, but also IL-1 alpha and CSF-1, usually synthesized by accessory cells. CD28 functions as a cell adhesion molecule (CAM) for certain T cell subsets.
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